Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 3/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551481 | 0.99 | SETD2 (0.34) | SMN1; SMN2LMNASETD2SLC6A9SLC6A5 | |
| SCHEMBL4551942 | 0.92 | FAAH (0.31) | SETD2SLC6A9SLC6A5TDP1 | |
| SCHEMBL4551887 | 0.88 | MAPK3 (0.35) | SLC6A9SLC6A5MAPK1PDE4BPLAU | |
| SCHEMBL4551650 | 0.86 | PDE4B (0.40) | SMN1; SMN2LMNASETD2MAPTMAPK1 | |
| SCHEMBL5490933 | 0.85 | PDE4B (0.41) | SETD2MAPTPDE4BRAF1BRAF | |
| SCHEMBL5490098 | 0.81 | MAPT (0.32) | SMN1; SMN2SETD2SLC6A9SLC6A5JAK2 | |
| SCHEMBL5490026 | 0.81 | CRHR1 (0.42) | SLC6A9SLC6A5MAPK1 | |
| SCHEMBL5494096 | 0.80 | CRHR1 (0.42) | — | |
| SCHEMBL5495528 | 0.80 | RPS6KA3 (0.35) | SLC6A9SLC6A5 | |
| SCHEMBL4551762 | 0.79 | RPS6KA3 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |