Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 7/20 | 0.39 |
| ▸ | RAF1 | P04049 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551566 | 0.91 | BRAF (0.49) | PLAUBRAFRAF1MAPK14 | |
| SCHEMBL4551775 | 0.87 | MAPT (0.48) | MAPTRAB9AKDM4EBRAFRAF1 | |
| SCHEMBL5604081 | 0.86 | RAF1 (0.42) | MAPTPLAUKDM4EBRAFRAF1 | |
| SCHEMBL4541474 | 0.85 | RAF1 (0.42) | PLAUKDM4EBRAFRAF1L3MBTL1 | |
| SCHEMBL4551703 | 0.82 | MAPK14 (0.48) | PLAUBRAFRAF1MAPK14 | |
| SCHEMBL5603996 | 0.82 | NAMPT (0.45) | MAPTBRAFRAF1TP53MAPK14 | |
| SCHEMBL4552281 | 0.82 | RAF1 (0.45) | PLAUBRAFRAF1MAPK14 | |
| SCHEMBL4551975 | 0.82 | L3MBTL1 (0.46) | MAPTRAB9AKDM4EALDH1A1NPC1 | |
| SCHEMBL4551493 | 0.81 | NAMPT (0.43) | MAPTBRAFRAF1TP53MAPK14 | |
| SCHEMBL5603194 | 0.80 | RAF1 (0.43) | PLAUALDH1A1BRAFRAF1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |