⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304378 | 0.93 | FAAH (0.48) | — | |
| SCHEMBL1415946 | 0.86 | — | — | |
| SCHEMBL128295 | 0.79 | — | — | |
| SCHEMBL11570155 | 0.78 | CNR1 (0.48) | — | |
| SCHEMBL129603 | 0.77 | NAAA (0.43) | — | |
| SCHEMBL450031 | 0.76 | CA1 (0.39) | — | |
| SCHEMBL133540 | 0.76 | ALDH1A1 (0.46) | — | |
| SCHEMBL7293172 | 0.76 | CES1 (0.42) | — | |
| SCHEMBL1415936 | 0.75 | — | — | |
| SCHEMBL449511 | 0.74 | ALDH1A1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756096-B1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-08-12 | — | — | EP | claimed |
| EP-0957908-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-03-12 | — | — | EP | claimed |
| EP-1023295-A4 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO INC (US) | 2001-01-24 | — | — | EP | claimed |
| EP-1061934-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-12-27 | — | — | EP | claimed |
| EP-1023295-A1 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | claimed |
| EP-0957908-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1999-11-24 | — | — | EP | claimed |
| US-5981584-A | USEFUL IN THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING THE AGGREGATION OF BLOOD PLATELETS, INHIBITING ANGIOGENESIS, INHIBITING OSTEOCLAST MEDIATED BONE RESORPTION, PREVENTING PLATELET THROMBOSIS | MERCK & CO., INC. (US) | 1999-11-09 | — | — | US | claimed |
| WO-1999045939-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-09-16 | — | — | WO | claimed |
| US-5945545-A | SUBSTITIUTED AMIDINOBENZENE COMPOUNDS; ANTICOAGULANTS | MERCK & CO., INC. (US) | 1999-08-31 | — | — | US | claimed |
| WO-1998034935-A1 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO., INC. (US) | 1998-08-13 | — | — | WO | claimed |
| WO-1998025601-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | claimed |
| EP-0957908-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1023295-A4 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO INC (US) | 2001-01-24 | — | — | EP | disclosed |
| EP-1061934-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-12-27 | — | — | EP | disclosed |
| US-6117842-A | INHIBITION OF BINDING OF FIBRINOGEN AND OTHER PROTEINS TO BLOOD PLATELETS, AND INHIBITING AGGREGATION OF BLOOD PLATELETS; | MERCK & CO., INC. (US) | 2000-09-12 | — | — | US | disclosed |
| US-5981584-A | USEFUL IN THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING THE AGGREGATION OF BLOOD PLATELETS, INHIBITING ANGIOGENESIS, INHIBITING OSTEOCLAST MEDIATED BONE RESORPTION, PREVENTING PLATELET THROMBOSIS | MERCK & CO., INC. (US) | 1999-11-09 | — | — | US | disclosed |
| WO-1999045939-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-09-16 | — | — | WO | disclosed |
| US-5945545-A | SUBSTITIUTED AMIDINOBENZENE COMPOUNDS; ANTICOAGULANTS | MERCK & CO., INC. (US) | 1999-08-31 | — | — | US | disclosed |
| WO-1998034935-A1 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO., INC. (US) | 1998-08-13 | — | — | WO | disclosed |
| WO-1998025601-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | disclosed |