Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.38 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18039975 | 0.81 | KDM4E (0.40) | KDM4EHPGDALDH1A1NPSR1CNR1 | |
| SCHEMBL1493280 | 0.80 | HTT (0.54) | KDM4EHPGDALDH1A1NPSR1CNR1 | |
| SCHEMBL16648631 | 0.80 | SMN1; SMN2 (0.57) | KDM4EHPGDALDH1A1NPSR1JAK2 | |
| SCHEMBL18039882 | 0.78 | KDM4E (0.37) | KDM4EHPGDALDH1A1NPSR1CNR1 | |
| SCHEMBL19385266 | 0.73 | USP30 (0.59) | NPSR1JAK2JAK1TRPC3TRPC7 | |
| SCHEMBL18625213 | 0.71 | HTR2B (0.49) | TLR9TLR8TLR7KDM4EHPGD | |
| SCHEMBL793658 | 0.71 | RAB9A (0.49) | HPGDALDH1A1JAK2JAK1GPR119 | |
| SCHEMBL3639005 | 0.70 | QDPR (0.50) | TLR9TLR8TLR7TRPC6 | |
| SCHEMBL704010 | 0.70 | RAB9A (0.51) | TLR9TLR8TLR7HPGDALDH1A1 | |
| SCHEMBL18039912 | 0.70 | ALOX15 (0.48) | TLR9TLR8TLR7KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |