Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 14/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555437 | 0.87 | FFAR1 (0.38) | FFAR1USP7 | |
| SCHEMBL4553186 | 0.86 | FFAR1 (0.44) | FFAR1NOD1HTTMEN1LMNA | |
| SCHEMBL4554891 | 0.83 | FFAR1 (0.44) | FFAR1 | |
| SCHEMBL3728485 | 0.77 | ESR2 (0.47) | FFAR1NOD1MEN1RAB9AKMT2A | |
| SCHEMBL3664740 | 0.73 | SMN1; SMN2 (0.54) | NOD1HTTMEN1LMNAMAPT | |
| SCHEMBL3727106 | 0.73 | FFAR1 (0.47) | FFAR1HTTMEN1LMNAMAPT | |
| SCHEMBL4555617 | 0.73 | ALDH1A1 (0.41) | HTTLMNAMAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3725782 | 0.72 | FFAR1 (0.47) | FFAR1HTTMEN1LMNAMAPT | |
| SCHEMBL4555438 | 0.72 | MTNR1B (0.38) | FFAR1 | |
| SCHEMBL26133355 | 0.72 | RAB9A (0.47) | MEN1LMNARAB9AKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125799-A1 | THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008104524-A1 | THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-04 | — | — | WO | disclosed |