Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 5/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555122 | 0.91 | MAPK8 (0.37) | SMN1; SMN2CYP1A2CYP2C19GALR3CYP3A4 | |
| SCHEMBL4570493 | 0.88 | PHGDH (0.36) | MEN1KMT2APTGDR2MCL1PLA2G4A | |
| SCHEMBL4553883 | 0.87 | SMN1; SMN2 (0.33) | SMN1; SMN2MEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL4554740 | 0.87 | AGTR2 (0.37) | MCL1PLA2G4APPARG | |
| SCHEMBL4554652 | 0.86 | GABRA1 (0.36) | SMN1; SMN2CYP1A2CYP2C19GALR3CYP3A4 | |
| SCHEMBL4554828 | 0.84 | AGTR2 (0.38) | SMN1; SMN2CYP1A2CYP2C19GALR3CYP3A4 | |
| SCHEMBL963395 | 0.83 | KMT2A (0.37) | SMN1; SMN2MEN1KMT2APTGDR2PLA2G4A | |
| SCHEMBL4554438 | 0.82 | MAPK8 (0.35) | SMN1; SMN2CYP1A2CYP2C19GALR3CYP3A4 | |
| SCHEMBL4554288 | 0.81 | TP53 (0.38) | SMN1; SMN2MEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL5115435 | 0.81 | KMO (0.38) | SMN1; SMN2KMT2APTGDR2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |