Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553762 | 0.95 | AGTR2 (0.37) | MCL1PPARGAGTR2 | |
| SCHEMBL4554740 | 0.89 | AGTR2 (0.37) | MCL1PPARGPLA2G4AAGTR2 | |
| SCHEMBL4554505 | 0.88 | NPY5R (0.34) | MCL1HTTSMN1; SMN2GALR3CYP1A2 | |
| SCHEMBL5115435 | 0.88 | KMO (0.38) | MAPK8MAPK9MAPK10MCL1HTT | |
| SCHEMBL4555122 | 0.87 | MAPK8 (0.37) | MAPK8MAPK9MAPK10MCL1HTT | |
| SCHEMBL966058 | 0.86 | TP53 (0.38) | MAPK8MCL1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL963019 | 0.84 | TP53 (0.37) | MAPK8MCL1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL4554828 | 0.83 | AGTR2 (0.38) | MCL1HTTSMN1; SMN2GALR3CYP1A2 | |
| SCHEMBL4553444 | 0.82 | SMN1; SMN2 (0.44) | MCL1HTTSMN1; SMN2GALR3CYP1A2 | |
| SCHEMBL4553883 | 0.82 | SMN1; SMN2 (0.33) | MAPK8MAPK9MAPK10MCL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |