Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 12/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554438 | 0.95 | MAPK8 (0.35) | AGTR2PPARGMCL1 | |
| SCHEMBL4554740 | 0.94 | AGTR2 (0.37) | AGTR2AGTR1PPARGMCL1 | |
| SCHEMBL4554505 | 0.86 | NPY5R (0.34) | AGTR2MCL1 | |
| SCHEMBL5115435 | 0.86 | KMO (0.38) | PPARGMCL1 | |
| SCHEMBL963019 | 0.86 | TP53 (0.37) | PPARGMCL1 | |
| SCHEMBL4555122 | 0.86 | MAPK8 (0.37) | MCL1 | |
| SCHEMBL4554828 | 0.84 | AGTR2 (0.38) | AGTR2AGTR1PPARGMCL1 | |
| SCHEMBL966058 | 0.84 | TP53 (0.38) | PPARGMCL1 | |
| SCHEMBL4553883 | 0.81 | SMN1; SMN2 (0.33) | PPARGMCL1 | |
| SCHEMBL4553444 | 0.81 | SMN1; SMN2 (0.44) | PPARGMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |