Sugi Predict

Sugi Predict / Compounds / Phenol

Phenol

Phenol

SCHEMBL45542

CCCC(O)=C(C)C(N)=O.Oc1ccccc1

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B3 P37058 3/20 0.42
▸ ALOX5 P09917 1/20 0.41
▸ CES2 O00748 2/20 0.41
▸ CES1 P23141 2/20 0.41
▸ ESR1 P03372 2/20 0.40
▸ L3MBTL1 Q9Y468 2/20 0.39
▸ HPGD P15428 2/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ ALDH1A1 P00352 3/20 0.38
▸ CYP2C19 P33261 2/20 0.38
▸ RECQL P46063 1/20 0.38
▸ GLA P06280 2/20 0.38
▸ CA12 O43570 1/20 0.38
▸ CA1 P00915 1/20 0.38
▸ CA2 P00918 1/20 0.38
▸ CA3 P07451 1/20 0.38
▸ CA4 P22748 1/20 0.38
▸ CA9 Q16790 1/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38
▸ CA14 Q9ULX7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenol SCHEMBL1415085 1.00 HSD17B3 (0.42) HSD17B3ALOX5CES2CES1ESR1
SCHEMBL45044 0.83 HDAC3 (0.43) CES2CES1ESR1ALDH1A1TDP1
SCHEMBL1075702 0.83 HDAC3 (0.43) CES2CES1ESR1ALDH1A1TDP1
Phenol SCHEMBL28106942 0.77 ALDH1A1 (0.52) HSD17B3ALOX5CES2CES1ESR1
Phenol SCHEMBL28594893 0.76 HDAC3 (0.54) HSD17B3ALOX5CES2CES1ESR1
Phenol SCHEMBL2369589 0.75 HDAC3 (0.59) HSD17B3ALOX5CES2CES1ESR1
Phenol SCHEMBL28578978 0.75 TDP1 (0.55) HSD17B3ALOX5CES2CES1ESR1
Phenol SCHEMBL5934375 0.74 TDP1 (0.61) ALOX5CES2CES1ESR1L3MBTL1
Phenol SCHEMBL28833788 0.74 TDP1 (0.61) ALOX5CES2CES1ESR1L3MBTL1
Phenol SCHEMBL28682879 0.74 CES1 (0.55) HSD17B3ALOX5CES2CES1ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1732 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6514978-B2 Compounds such as 1-(n-(2-(amidinoaminooxy)ethyl)amino) carbonylmethyl-6-methyl-3-(phenethylamino)-pyrazinone attached to a polymer coated onto a medical device for blood collection or storage; antiagglomerants 3-DIMENSIONAL PHARMACEUTICALS, INC. 2003-02-04 — — US claimed
US-20010021713-A1 Thromboresistant materials incorporating pyrazinone protease inhibitors LU TIANBAO (US) 2001-09-13 — — US claimed
US-12043610-B2 Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2024-07-23 — — US disclosed
US-RE50050-E1 Pyrimidinedione compounds MyoKardia, Inc. (US) 2024-07-23 — — US disclosed
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-07-18 — — US disclosed
US-20240239740-A1 TREATMENT OF SLEEP-WAKE DISORDERS SK BIOPHARMACEUTICALS CO LTD (KR) 2024-07-18 — — US disclosed
EP-3873904-B1 TETRAHYDROPYRAN (THP)-SUBSTITUTED BICYCLIC-PYRIMIDINEDIONE COMPOUNDS MYOKARDIA INC (US) 2024-07-10 — — EP disclosed
CN-113307772-B Human plasma kallikrein inhibitors 拜奥克里斯特制药公司 2024-06-28 — — CN disclosed
EP-4387965-A2 ARYL SULFONYL COMPOUNDS AS CCR6 INHIBITORS ChemoCentryx, Inc. (US) 2024-06-26 — — EP disclosed
EP-4387609-A2 ARYL SULFONYL (HYDROXY) PIPERIDINES AS CCR6 INHIBITORS ChemoCentryx, Inc. (US) 2024-06-26 — — EP disclosed
US-12018016-B2 Aryl sulfonyl (hydroxy) piperidines as CCR6 inhibitors AMGEN INC. (US) 2024-06-25 — — US disclosed
US-5397791-A Anticoagulants MERCK & CO., INC. (US) 1995-03-14 — — US disclosed
WO-1995004531-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1995-02-16 — — WO disclosed
WO-1994029338-A1 THROMBIN RECEPTOR RADIOLIGANDS AND ASSAYS FOR IDENTIFYING THROMBIN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1994-12-22 — — WO disclosed
WO-1994026745-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1994-11-24 — — WO disclosed
WO-1994025051-A1 THROMBIN INHIBITORS MERCK & CO., INC. (US) 1994-11-10 — — WO disclosed
WO-1994018981-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1994-09-01 — — WO disclosed
US-5340798-A Platelet antiagglomerants MERCK & CO., INC. (US) 1994-08-23 — — US disclosed
US-5334596-A Anticoagulants MERCK & CO., INC. (US) 1994-08-02 — — US disclosed
WO-1994009029-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1994-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12018016-B2 Aryl sulfonyl (hydroxy) piperidines as CCR6 inhibitors CCR6, CCR1, CCR4 HSD17B3 2868/4885ALOX5 3373/4885CES2 146/4885
US-20240239740-A1 TREATMENT OF SLEEP-WAKE DISORDERS HCRTR1, HCRTR2, MTNR1B HSD17B3 67/4885ALOX5 682/4885CES2 226/4885
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 KLK5, KLK1, KLKB1 HSD17B3 30/4885ALOX5 1408/4885CES2 1268/4885
US-12043610-B2 Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors C9, C5, C1QBP HSD17B3 2063/4885ALOX5 221/4885CES2 1260/4885
US-20010021713-A1 Thromboresistant materials incorporating pyrazinone protease inhibitors HPN, SERPINE1, SERPINC1 HSD17B3 910/4885ALOX5 3060/4885CES2 1814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.