Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554365 | 0.81 | KDM4E (0.44) | KDM2BKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5915128 | 0.77 | HTR2C (0.51) | KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL18037807 | 0.76 | KMO (0.44) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4554838 | 0.74 | CHRM1 (0.40) | ALDH1A1KMT2A | |
| SCHEMBL18766586 | 0.72 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL18766587 | 0.72 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL28046983 | 0.70 | NPC1 (0.54) | KDM4EALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL16057602 | 0.69 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL27903451 | 0.69 | PARP1 (0.52) | KDM2BHRH3PARP1 | |
| SCHEMBL14648297 | 0.69 | LIPG (0.42) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |