Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL962802 | 0.88 | MAPT (0.45) | MAPTCYP19A1CDC7CDK2RAPGEF4 | |
| SCHEMBL4553928 | 0.84 | CA12 (0.35) | MAPTCDC7CDK2RAPGEF4 | |
| SCHEMBL962758 | 0.84 | ALDH1A1 (0.47) | MAPTCYP19A1CDC7CDK2 | |
| SCHEMBL962759 | 0.84 | ALDH1A1 (0.47) | MAPTCYP19A1CDC7CDK2 | |
| SCHEMBL4554908 | 0.81 | CDC7 (0.37) | MAPTCDC7CDK2 | |
| SCHEMBL964749 | 0.80 | CCNC (0.47) | MAPTCYP19A1 | |
| SCHEMBL4554187 | 0.79 | HTR2A (0.33) | — | |
| SCHEMBL4553105 | 0.79 | ROCK1 (0.41) | MAPT | |
| SCHEMBL4553594 | 0.78 | KDM4E (0.35) | MAPT | |
| SCHEMBL4553471 | 0.78 | SMN1; SMN2 (0.38) | MAPTCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |