Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MELK | Q14680 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555146 | 0.87 | DPP4 (0.32) | L3MBTL3L3MBTL1HCRTR1HCRTR2 | |
| SCHEMBL4554617 | 0.75 | GPR119 (0.35) | — | |
| SCHEMBL4555483 | 0.73 | L3MBTL3 (0.36) | L3MBTL3L3MBTL1MELK | |
| SCHEMBL4555173 | 0.72 | L3MBTL3 (0.35) | L3MBTL3L3MBTL1 | |
| SCHEMBL4555417 | 0.68 | CTSS (0.33) | L3MBTL3L3MBTL1 | |
| SCHEMBL4553619 | 0.67 | LRRK2 (0.38) | L3MBTL3L3MBTL1MELK | |
| SCHEMBL4554607 | 0.66 | L3MBTL3 (0.38) | L3MBTL3L3MBTL1 | |
| SCHEMBL4555362 | 0.66 | L3MBTL3 (0.43) | L3MBTL3L3MBTL1 | |
| SCHEMBL4555143 | 0.66 | L3MBTL3 (0.32) | L3MBTL3L3MBTL1 | |
| SCHEMBL4555154 | 0.66 | GPR119 (0.39) | L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |