Sugi Predict

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SCHEMBL4554956

SCHEMBL4554956

NS(=O)(=O)c1ccc(NC(=O)Nc2cccc(F)c2)cc1

nearest known ligand 0.74

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CA2 P00918 16/20 0.74
▸ CA12 O43570 12/20 0.74
▸ CA1 P00915 12/20 0.74
▸ CA9 Q16790 12/20 0.74
▸ CA4 P22748 1/20 0.72
▸ CA7 P43166 1/20 0.72
▸ KMT2A Q03164 3/20 0.71
▸ MEN1 O00255 2/20 0.71
▸ GAA P10253 1/20 0.71
▸ RAB9A P51151 1/20 0.71
▸ L3MBTL1 Q9Y468 1/20 0.70
▸ ALDH1A1 P00352 1/20 0.67
▸ CA5A P35218 1/20 0.65
▸ CA5B Q9Y2D0 1/20 0.65
▸ MAPT P10636 2/20 0.64
▸ CYP1A2 P05177 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL672734 0.85 CA2 (1.00) CA2CA12CA1CA9CA4
Slc-0111 SCHEMBL672955 0.84 CA1 (1.00) CA2CA12CA1CA9CA4
SCHEMBL20822191 0.84 CA2 (0.72) CA2CA12CA1CA9CA4
SCHEMBL671546 0.82 CA2 (1.00) CA2CA12CA1CA9CA4
SCHEMBL18361655 0.82 ALDH1A1 (0.60) CA2CA12CA1CA9CA4
SCHEMBL671610 0.82 CA2 (1.00) CA2CA12CA1CA9KMT2A
SCHEMBL13784930 0.82 CA2 (0.76) CA2CA12CA1CA9KMT2A
SCHEMBL3409517 0.82 CA2 (0.77) CA2CA12CA1CA9CA4
SCHEMBL19379986 0.82 CA2 (0.73) CA2CA12CA1CA9KMT2A
SCHEMBL28499329 0.82 KMT2A (1.00) CA2CA12CA1CA9CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9932300-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2018-04-03 — — US disclosed
US-20160318857-A1 N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2016-11-03 — — US disclosed
US-9421211-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2016-08-23 — — US disclosed
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-05-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160318857-A1 N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation NSUN2, EIF2AK2, RNGTT CA2 4787/4885CA12 4766/4885CA1 4604/4885
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION NSUN2, EIF2AK2, RNGTT CA2 4787/4885CA12 4766/4885CA1 4604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.