Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1192038 | 0.67 | MPO (0.47) | MPOMAPK14ROCK2ROCK1NPC1 | |
| SCHEMBL4278562 | 0.67 | CLK4 (0.60) | SMN1; SMN2MAPK14ROCK2ROCK1MAPT | |
| SCHEMBL27481686 | 0.64 | MAPK14 (0.55) | MAPK14ROCK1MEN1MAPTKMT2A | |
| SCHEMBL410765 | 0.63 | MPO (0.51) | MPOSMN1; SMN2ROCK1ALDH1A1LMNA | |
| SCHEMBL28145908 | 0.63 | ALDH1A1 (0.56) | MPODRD2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL21384082 | 0.62 | MPO (0.44) | MPODRD2KCNH2SMN1; SMN2MEN1 | |
| SCHEMBL21384289 | 0.62 | ADCY10 (0.42) | MPODRD2KCNH2SMN1; SMN2MEN1 | |
| SCHEMBL21384018 | 0.62 | ALDH1A1 (0.54) | MPODRD2KCNH2SMN1; SMN2MEN1 | |
| SCHEMBL29442843 | 0.62 | ALDH1A1 (0.54) | MPODRD2KCNH2SMN1; SMN2MEN1 | |
| SCHEMBL27876845 | 0.62 | LOXL2 (0.65) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009126635-A1 | 2-AMINO-BENZOTHIAZOLE DERIVATES USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | WO | disclosed |