Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2695169 | 0.98 | HPGD (0.58) | HPGDTP53SMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL11841082 | 0.84 | TP53 (0.58) | HPGDTP53RAB9ANPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11834603 | 0.84 | TP53 (0.58) | HPGDTP53RAB9ANPC1ALDH1A1 | |
| SCHEMBL16671797 | 0.84 | KDM4E (0.59) | HPGDRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL7865528 | 0.84 | KDM4E (0.69) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11836563 | 0.83 | HPGD (0.48) | HPGDTP53SMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL5801075 | 0.83 | HPGD (0.48) | HPGDTP53SMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL11845983 | 0.83 | KDM4E (0.67) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5550609 | 0.83 | KDM4E (0.58) | HPGDRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL17213443 | 0.83 | HPGD (0.62) | HPGDTP53SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4606791-B1 | IMPROVED PROCESS FOR THE PREPARATION OF INDOMETHACIN | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2026-04-08 | — | — | EP | claimed |
| EP-4606791-A1 | IMPROVED PROCESS FOR THE PREPARATION OF INDOMETHACIN | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2025-08-27 | — | — | EP | claimed |
| US-20250263373-A1 | PROCESS FOR THE PREPARATION OF INDOMETHACIN | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2025-08-21 | — | — | US | claimed |
| EP-4606791-B1 | IMPROVED PROCESS FOR THE PREPARATION OF INDOMETHACIN | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2026-04-08 | — | — | EP | disclosed |
| EP-4606791-A1 | IMPROVED PROCESS FOR THE PREPARATION OF INDOMETHACIN | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2025-08-27 | — | — | EP | disclosed |
| EP-4606791-A1 | IMPROVED PROCESS FOR THE PREPARATION OF INDOMETHACIN | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2025-08-27 | — | — | EP | disclosed |
| CN-120518519-A | Improved process for preparing indomethacin | F.I.S.菲博利佳意大利合成面料股份公司 | 2025-08-22 | — | — | CN | disclosed |
| US-20250263373-A1 | PROCESS FOR THE PREPARATION OF INDOMETHACIN | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2025-08-21 | — | — | US | disclosed |
| US-20250263373-A1 | PROCESS FOR THE PREPARATION OF INDOMETHACIN | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2025-08-21 | — | — | US | disclosed |
| US-20210198197-A1 | METHOD FOR SYNTHESIZING INDOMETHACIN AND ANALOGUE THEREOF | HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2021-07-01 | — | — | US | disclosed |
| US-8168656-B2 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090118290-A1 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY | 2009-05-07 | — | — | US | disclosed |
| US-7491744-B2 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY (US) | 2009-02-17 | — | — | US | disclosed |
| CN-1141627-A | Indole derivatives for the treatment of estrogen-related tumors and diseases | MERRELL DOW PHARMA (US) | 1997-01-29 | — | — | CN | disclosed |
| US-4165428-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, ANTIPYRETICS | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 1979-08-21 | — | — | US | disclosed |
| US-3962471-A | Indolylacetylamino acid derivatives, process for their preparation, and pharmaceutical compositions | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210198197-A1 | METHOD FOR SYNTHESIZING INDOMETHACIN AND ANALOGUE THEREOF | IDO1, IDO2, PTGIS | HPGD 19/4885TP53 1515/4885SMN1; SMN2 4675/4885 |
| US-20090118290-A1 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | AANAT, FABP2, SI | HPGD 65/4885TP53 742/4885SMN1; SMN2 4227/4885 |
| US-20250263373-A1 | PROCESS FOR THE PREPARATION OF INDOMETHACIN | ADH1C, ADH1A, F12 | HPGD 173/4885TP53 4286/4885SMN1; SMN2 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.