Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | BCL3 | P20749 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27362945 | 0.88 | POLB (0.66) | CYP2C9CYP2C19POLBALDH1A1TSHR | |
| SCHEMBL28602004 | 0.83 | POLB (0.60) | CYP2C9CYP2C19POLBBCL3MEN1 | |
| SCHEMBL13164059 | 0.83 | MEN1 (0.66) | POLBALDH1A1BCL3MEN1KMT2A | |
| SCHEMBL280010 | 0.81 | P2RX7 (0.59) | POLBALDH1A1BCL3MEN1KMT2A | |
| SCHEMBL29530276 | 0.77 | LMNA (0.73) | CYP2C9CYP2C19POLBLMNAALDH1A1 | |
| SCHEMBL10363079 | 0.77 | ALDH1A1 (0.61) | POLBLMNAALDH1A1BCL3GAA | |
| SCHEMBL16431474 | 0.76 | BCL3 (0.76) | POLBLMNAALDH1A1BCL3GAA | |
| SCHEMBL29849750 | 0.76 | BCL3 (0.76) | POLBLMNAALDH1A1BCL3GAA | |
| SCHEMBL7298894 | 0.76 | ALDH1A1 (0.56) | CYP2C9CYP2C19POLBLMNAALDH1A1 | |
| SCHEMBL2362567 | 0.76 | POLB (0.66) | POLBLMNAALDH1A1BCL3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |