SCHEMBL4556754

SCHEMBL4556754

C#CNC(=O)c1ccc(Cl)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.55
KDM4E B2RXH2 1/20 0.55
LMNA P02545 1/20 0.55
MAPT P10636 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
TSHR P16473 2/20 0.52
CYP1A2 P05177 1/20 0.52
NFKB1 P19838 1/20 0.52
MAOB P27338 1/20 0.52
KMT2A Q03164 3/20 0.50
PTGS2 P35354 2/20 0.50
MEN1 O00255 2/20 0.50
BLM P54132 1/20 0.50
PMP22 Q01453 1/20 0.50
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
POLB P06746 2/20 0.47
RXFP1 Q9HBX9 1/20 0.47
FLT1 P17948 1/20 0.47
FLT4 P35916 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7468252 0.81 GFER (0.54) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL2479115 0.79 ALDH1A1 (0.55) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL300028 0.78 ALOX15 (0.54) ALDH1A1KDM4EMAPTTSHRKMT2A
SCHEMBL17099954 0.78 ALDH1A1 (0.53) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL29094183 0.76 ALDH1A1 (0.52) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL15047786 0.75 MAPT (0.67) ALDH1A1KDM4ELMNAMAPTL3MBTL1
Cyanamide SCHEMBL8891222 0.75 ALDH1A1 (0.55) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL18704329 0.75 CA12 (0.63) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL202512 0.73 HDAC1 (0.65) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL8606592 0.73 ALDH1A1 (0.64) ALDH1A1KDM4ELMNAMAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1366013-B1 A PROCESS FOR THE PREPARATION OF FIBRATES SOLCHEM ITALIANA SPA (IT) 2007-08-01 EP claimed
EP-0245156-B1 PREPARATION OF FIBRATES FOURNIER INNOVATION ET SYNERGIE (FR) 1990-01-03 EP claimed
EP-0245156-A1 Preparation of fibrates FOURNIER INNOVATION ET SYNERGIE (FR) 1987-11-11 EP claimed
EP-1940772-B1 NOVEL METHOD FOR PREPARING QUATERNARY ACID AND AMMONIUM SALTS FOURNIER LAB IRELAND LTD (IE) 2009-08-05 EP disclosed
EP-1940772-A1 NOVEL METHOD FOR PREPARING QUATERNARY ACID AND AMMONIUM SALTS Fournier Laboratories Ireland Limited (IE) 2008-07-09 EP disclosed
EP-1366013-B1 A PROCESS FOR THE PREPARATION OF FIBRATES SOLCHEM ITALIANA SPA (IT) 2007-08-01 EP disclosed
WO-2007048986-A1 NOVEL METHOD FOR PREPARING QUATERNARY ACID AND AMMONIUM SALTS FOURNIER LABORATORIES IRELAND LTD (IE) 2007-05-03 WO disclosed
EP-1366013-A1 A PROCESS FOR THE PREPARATION OF FIBRATES Solchem Italiana S.p.A (IT) 2003-12-03 EP disclosed
WO-2002062743-A1 A PROCESS FOR THE PREPARATION OF FIBRATES SOLCHEM ITALIANA S.P.A. (IT) 2002-08-15 WO disclosed
EP-0245156-B1 PREPARATION OF FIBRATES FOURNIER INNOVATION ET SYNERGIE (FR) 1990-01-03 EP disclosed
EP-0245156-A1 Preparation of fibrates FOURNIER INNOVATION ET SYNERGIE (FR) 1987-11-11 EP disclosed
EP-0245156-A1 Preparation of fibrates FOURNIER INNOVATION ET SYNERGIE (FR) 1987-11-11 EP disclosed