Hydrochloric Acid

Hydrochloric Acid

SCHEMBL455676

CN(C)c1ccc2nc3c(ccc4ccccc43)[o+]c2c1.[Cl-]

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.47
TERT O14746 1/20 0.39
APP P05067 1/20 0.39
MAOA P21397 1/20 0.39
SLC2A1 P11166 1/20 0.37
S100A4 P26447 1/20 0.36
CNR2 P34972 1/20 0.36
PSMB5 P28074 2/20 0.35
KDM1A O60341 6/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CYP3A4 P08684 2/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34
GLA P06280 1/20 0.34
CYP2D6 P10635 1/20 0.34
MAPT P10636 1/20 0.34
CYP2C9 P11712 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL917550 0.99 ALOX5 (0.46) ALOX5TERTAPPMAOASLC2A1
SCHEMBL108909 0.99 ALOX5 (0.48) ALOX5TERTAPPMAOASLC2A1
SCHEMBL30014307 0.84 TERT (0.44) ALOX5TERTMAOASLC2A1KDM1A
SCHEMBL1502498 0.76 NPC1 (0.40) MAOASLC2A1L3MBTL1CYP3A4KDM4E
Methylamine SCHEMBL4656918 0.75 MAOA (0.39) ALOX5MAOASLC2A1L3MBTL1CYP3A4
Hydrochloric Acid SCHEMBL10845581 0.74 KDM4E (0.41) CYP3A4KDM4EALDH1A1LMNACYP1A2
SCHEMBL10865905 0.73 KDM4E (0.42) KDM1ACYP3A4KDM4EALDH1A1LMNA
Hydrochloric Acid SCHEMBL3396268 0.69 ACP1 (0.38) KDM1AL3MBTL1KDM4EALDH1A1LMNA
SCHEMBL23183323 0.69 ALDH1A1 (0.56) ALOX5TERTAPPS100A4L3MBTL1
Hydrochloric Acid SCHEMBL2478045 0.69 TERT (0.54) TERTAPPPSMB5L3MBTL1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 275 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2245174-B1 IMPROVED REAGENT COMPOSITIONS FOR USE IN ELECTROCHEMICAL DETECTION NIPRO DIAGNOSTICS INC (US) 2012-11-21 EP claimed
US-8062490-B2 Reagent compositions for use in electrochemical detection NIPRO DIAGNOSTICS, INC. (US) 2011-11-22 US claimed
EP-2245174-A2 IMPROVED REAGENT COMPOSITIONS FOR USE IN ELECTROCHEMICAL DETECTION NIPRO DIAGNOSTICS, INC. (US) 2010-11-03 EP claimed
US-20100227355-A1 REAGENT COMPOSITIONS FOR USE IN ELECTROCHEMICAL DETECTION HOME DIAGNOSTICS, INC. (US) 2010-09-09 US claimed
US-7678250-B2 Reagent compositions for use in electrochemical detection HOME DIAGNOSTICS, INC. (US) 2010-03-16 US claimed
WO-2009094297-A2 IMPROVED REAGENT COMPOSITIONS FOR USE IN ELECTROCHEMICAL DETECTION HOME DIAGNOSTICS, INC. (US) 2009-07-30 WO claimed
US-20090186372-A1 Reagent Compositions For Use In Electrochemical Detection HOME DIAGNOSTICS, INC. 2009-07-23 US claimed
WO-2003022233-A1 AGENT FOR DYEING KERATIN FIBERS, CONTAINING A BLUE CATIONIC ANTHRAQUINONE DYE WELLA AKTIENGESELLSCHAFT (DE) 2003-03-20 WO claimed
EP-0600607-A2 Coulometric analysis method and a device therefor NAKANO VINEGAR CO., LTD. (JP) 1994-06-08 EP claimed
EP-2930126-B1 Fashionable aerosol dye HENKEL AG & CO KGAA (DE) 2019-10-09 EP disclosed
US-10259946-B1 Sealing agents, methods of making and uses thereof James Hardie Technology Limited (IE) 2019-04-16 US disclosed
EP-2797577-B1 COMPOSITIONS FOR DYEING KERATIN FIBERS HENKEL AG & CO KGAA (DE) 2018-06-13 EP disclosed
US-9901529-B2 Hair color composition ALFA PARF GROUP S.P.A. (IT) 2018-02-27 US disclosed
EP-2044977-B1 Hair dye with oxidative pre-treatment HENKEL AG & CO KGAA (DE) 2018-02-14 EP disclosed
US-6171347-B1 REMOVAL OF HAIR COLOR TO BE WORN FOR ONLY A SHORT PERIOD OF TIME UNDER MILD, GENTLE CONDITIONS BY USING A COMBINATION OF A SUITABLE REDUCTONE, SUCH AS ASCORBIC ACID, AND/OR A THIOL AND/OR A SULFITE WELLA AKTIENGESELLSCHAFT (DE) 2001-01-09 US disclosed
US-6106579-A MIXTURE OF OXOCARBOXYLIC ACID AND REDUCING AGENT WELLA AKTIENGESELLSCHAFT (DE) 2000-08-22 US disclosed
EP-1002516-A1 Hair dyes containing indan derivatives Wella Aktiengesellschaft (DE) 2000-05-24 EP disclosed
EP-0943316-A2 Means for coloring and decoloring of hair Wella Aktiengesellschaft (DE) 1999-09-22 EP disclosed
EP-0898954-A2 Composition for dyeing keratin fibres Wella Aktiengesellschaft (DE) 1999-03-03 EP disclosed
EP-0867171-A2 Powder composition for the preparation of gels comprising a methyl hydroxyalkyl cellulose Wella Aktiengesellschaft (DE) 1998-09-30 EP disclosed