Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774301 | 0.90 | CYP2C19 (0.41) | SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL4560387 | 0.86 | RXRA (0.44) | KIF11SMN1; SMN2PTPN5LMNA | |
| SCHEMBL15070049 | 0.79 | TSHR (0.46) | SMN1; SMN2MAPTALDH1A1LMNAHTT | |
| SCHEMBL6797392 | 0.78 | TSHR (0.46) | KIF11SMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL9717199 | 0.76 | MEN1 (0.45) | SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL28276711 | 0.76 | CA1 (0.34) | CYP2C9SMN1; SMN2MAPTALDH1A1DRD3 | |
| SCHEMBL5166644 | 0.76 | TP53 (0.39) | KIF11SMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL9714690 | 0.76 | ESR1 (0.54) | HPGDALDH1A1LMNA | |
| SCHEMBL192853 | 0.75 | KIF11 (0.48) | KIF11CYP2C9SMN1; SMN2MAPTPTPN5 | |
| SCHEMBL700444 | 0.75 | KIF11 (0.48) | KIF11CYP2C9SMN1; SMN2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291988-A1 | Reversible Inhibitors of Monoamine Oxidase A and B | MERCK FROSST CANADA LTD. (CA) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291988-A1 | Reversible Inhibitors of Monoamine Oxidase A and B | MAOB, MAOA, XDH | KIF11 4535/4885CYP2C9 109/4885SMN1; SMN2 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.