Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL156143 | 0.88 | LMNA (0.58) | HPGDLMNAMAPK1ALDH1A1CYP2D6 | |
| SCHEMBL8916370 | 0.88 | LMNA (0.58) | HPGDLMNAMAPK1ALDH1A1CYP2D6 | |
| SCHEMBL12824633 | 0.88 | LMNA (0.58) | HPGDLMNAMAPK1ALDH1A1CYP2D6 | |
| SCHEMBL4558925 | 0.81 | PTGS2 (0.67) | SMN1; SMN2L3MBTL1MAPTPTGS2HPGD | |
| SCHEMBL13777837 | 0.79 | NR1H2 (0.41) | L3MBTL1MAPK1FFAR1ALDH1A1 | |
| SCHEMBL11833508 | 0.79 | PTGS2 (0.49) | SMN1; SMN2L3MBTL1MAPTPTGS2HPGD | |
| Methacrylic Acid SCHEMBL29006645 | 0.79 | HPGD (0.56) | HPGDLMNAMAPK1ALDH1A1 | |
| SCHEMBL5513880 | 0.79 | ACHE (0.43) | SMN1; SMN2LMNAFFAR1ALDH1A1CYP3A4 | |
| SCHEMBL30785017 | 0.79 | PTGS2 (0.57) | SMN1; SMN2L3MBTL1MAPTPTGS2HPGD | |
| SCHEMBL7564005 | 0.78 | LMNA (0.74) | SMN1; SMN2MAPTPTGS2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291988-A1 | Reversible Inhibitors of Monoamine Oxidase A and B | MERCK FROSST CANADA LTD. (CA) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291988-A1 | Reversible Inhibitors of Monoamine Oxidase A and B | MAOB, MAOA, XDH | SMN1; SMN2 849/4885L3MBTL1 1098/4885MAPT 1254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.