Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | MLYCD | O95822 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CCR5 | P51681 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969869 | 0.75 | HTT (0.63) | HTTACHECHRM3CHRM2MEN1 | |
| SCHEMBL29273235 | 0.73 | LMNA (0.49) | HTTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL1190641 | 0.72 | POLB (0.61) | HTTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2724136 | 0.71 | HTT (0.71) | HTTACHEALDH1A1CHRM3CHRM2 | |
| SCHEMBL4153728 | 0.71 | ACHE (0.52) | HTTACHEALDH1A1CHRM1CHRM3 | |
| SCHEMBL27776801 | 0.71 | NPC1 (0.47) | HTTALDH1A1CHRM1CHRM3CHRM2 | |
| SCHEMBL30680668 | 0.70 | HTT (0.64) | HTTACHEALDH1A1MEN1KMT2A | |
| SCHEMBL30475562 | 0.70 | POLB (0.69) | ALDH1A1MEN1KMT2ALMNAKDM4E | |
| SCHEMBL18930513 | 0.70 | HTT (0.73) | HTTACHEALDH1A1MEN1KMT2A | |
| SCHEMBL6965223 | 0.70 | HTT (0.51) | HTTACHECHRM1CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | HTT 1010/4885ACHE 1885/4885ALDH1A1 532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.