Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 3/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493703 | 0.96 | ALDH1A1 (0.46) | ALDH1A1L3MBTL3L3MBTL1OPRD1KMT2A | |
| SCHEMBL493687 | 0.90 | L3MBTL1 (0.51) | ALDH1A1L3MBTL3L3MBTL1OPRD1KMT2A | |
| SCHEMBL4175324 | 0.80 | KMT2A (0.49) | ALDH1A1OPRD1KMT2AMEN1POLB | |
| SCHEMBL493492 | 0.80 | TDP1 (0.52) | ALDH1A1L3MBTL3L3MBTL1OPRD1KMT2A | |
| SCHEMBL5071337 | 0.79 | CCR5 (0.46) | ALDH1A1L3MBTL3L3MBTL1OPRD1KMT2A | |
| SCHEMBL27615098 | 0.77 | L3MBTL3 (0.52) | ALDH1A1L3MBTL3L3MBTL1CNR1CNR2 | |
| SCHEMBL16822513 | 0.77 | L3MBTL3 (0.51) | ALDH1A1L3MBTL3L3MBTL1OPRD1KMT2A | |
| SCHEMBL493765 | 0.77 | ALDH1A1 (0.63) | ALDH1A1L3MBTL3L3MBTL1KMT2AMEN1 | |
| SCHEMBL17888513 | 0.76 | KDM4E (0.59) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL2430876 | 0.76 | L3MBTL3 (0.48) | ALDH1A1L3MBTL3L3MBTL1OPRD1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024354-A1 | 1- [ (4- [BENZOYL (METHYL) AMINO]-3- (PHENYL) BUTYL]AZETIDINE DERIVATIVES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 1 | Albireo AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007136324-A1 | 1- [ (4- [BENZOYL (METHYL) AMINO] -3- (PHENYL) BUTYL] AZETIDINE DERIVATIVES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 1 | ALBIREO AB (SE) | 2007-11-29 | — | — | WO | disclosed |