Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28121828 | 0.87 | KMT2A (0.58) | HDAC1HDAC6AKR1C3MTNR1AMTNR1B | |
| SCHEMBL457499 | 0.86 | GPR84 (0.51) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL457128 | 0.84 | SLC5A1 (0.62) | ALDH1A1MAPTTDP1 | |
| SCHEMBL63100 | 0.82 | HDAC1 (0.61) | HDAC1HDAC6MTNR1AMTNR1BTAAR1 | |
| SCHEMBL455030 | 0.82 | KMT2A (0.59) | HDAC1AKR1C3GAAALDH1A1MAPT | |
| SCHEMBL454743 | 0.82 | FFAR1 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL27570217 | 0.81 | GAA (0.61) | AKR1C3GAACYP1A2ALDH1A1MAPT | |
| SCHEMBL30574244 | 0.81 | GABRA1 (0.87) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL29059722 | 0.80 | HDAC1 (0.52) | HDAC1HDAC6MTNR1AMTNR1BTAAR1 | |
| SCHEMBL456323 | 0.79 | SLC5A1 (0.72) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10800725-B2 | Arylpropionyl-triketone antibacterial agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-10-13 | — | — | US | disclosed |
| US-9517994-B2 | Antibacterial agents: phloroglucinol derivatives | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150011647-A1 | ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES | HOWARD HUGHES MEDICAL INSTITUTE | 2015-01-08 | — | — | US | disclosed |
| US-20130289128-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-10-31 | — | — | US | disclosed |
| WO-2013103969-A1 | ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2013-07-11 | — | — | WO | disclosed |
| WO-2012033846-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289128-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | POLR2H, POLR2A, POLR2E | GABRA1 3716/4885GABRG2 4352/4885GABRB3 3832/4885 |
| US-20150011647-A1 | ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES | BET1, MRPL21, PHF6 | GABRA1 4734/4885GABRG2 4323/4885GABRB3 4513/4885 |
| US-10800725-B2 | Arylpropionyl-triketone antibacterial agents | POLR2H, POLR2A, POLR2E | GABRA1 3716/4885GABRG2 4352/4885GABRB3 3832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.