Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 2/20 | 0.62 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.62 |
| ▸ | CALM1 | P0DP23 | 3/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877832 | 0.88 | CALM1 (0.62) | SLC5A1SLC5A2CALM1NFKB1NFKB2 | |
| SCHEMBL11246900 | 0.88 | CALM1 (0.62) | SLC5A1SLC5A2CALM1NFKB1NFKB2 | |
| SCHEMBL457502 | 0.86 | SLC5A1 (0.55) | SLC5A1SLC5A2CALM1NFKB1NFKB2 | |
| SCHEMBL15094539 | 0.86 | GPR84 (0.47) | SLC5A1SLC5A2CALM1NFKB1NFKB2 | |
| SCHEMBL14877841 | 0.85 | NFKB1 (0.57) | SLC5A1SLC5A2CALM1NFKB1NFKB2 | |
| SCHEMBL456324 | 0.84 | GABRA1 (0.58) | MAPTALDH1A1TDP1 | |
| SCHEMBL15094007 | 0.84 | GPR84 (0.51) | SLC5A1SLC5A2CALM1KMT2APOLB | |
| SCHEMBL455621 | 0.83 | FFAR1 (0.50) | SLC5A1SLC5A2CALM1NFKB1NFKB2 | |
| SCHEMBL454233 | 0.83 | AKR1C3 (0.45) | SLC5A1SLC5A2CALM1NFKB1NFKB2 | |
| SCHEMBL458223 | 0.83 | SLC5A1 (0.55) | SLC5A1SLC5A2CALM1FFAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10800725-B2 | Arylpropionyl-triketone antibacterial agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-10-13 | — | — | US | disclosed |
| US-20130289128-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-10-31 | — | — | US | disclosed |
| WO-2012033846-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289128-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | POLR2H, POLR2A, POLR2E | SLC5A1 2423/4885SLC5A2 3409/4885CALM1 4400/4885 |
| US-10800725-B2 | Arylpropionyl-triketone antibacterial agents | POLR2H, POLR2A, POLR2E | SLC5A1 2423/4885SLC5A2 3409/4885CALM1 4400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.