Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CLPP | Q16740 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30425163 | 0.76 | HSD17B10 (0.43) | ALDH1A1 | |
| SCHEMBL3934050 | 0.65 | HTR6 (0.61) | AKR1B1CA1CA2ALDH1A1 | |
| SCHEMBL9587491 | 0.64 | HTR6 (0.54) | HTR2CCYP19A1CA12CA1CA2 | |
| SCHEMBL9589105 | 0.63 | L3MBTL1 (0.54) | NAMPTNPY5RNPY1RCYP19A1CA12 | |
| Bromide SCHEMBL9586294 | 0.62 | L3MBTL1 (0.53) | NAMPTNPY5RNPY1RCYP19A1CA12 | |
| SCHEMBL13063330 | 0.61 | CYP2D6 (0.58) | — | |
| SCHEMBL9586629 | 0.61 | LOXL2 (0.50) | AKR1B1NPY5RNPY1RCYP19A1CA1 | |
| SCHEMBL11650307 | 0.60 | POLB (0.56) | ALDH1A1 | |
| SCHEMBL1952494 | 0.60 | LMNA (0.68) | AKR1B1CA1CA2 | |
| SCHEMBL19476153 | 0.60 | NAMPT (0.53) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041079-A1 | ARYLSULFONYL NAPHTHALENE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007147763-A1 | ARYLSULFONYL NAPHTHALENE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | WO | disclosed |