Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26985266 | 0.88 | UCHL1 (0.49) | RIPK1LMNATSHRNPC1UCHL1 | |
| SCHEMBL16881401 | 0.85 | ALDH1A1 (0.44) | RIPK1LMNATSHRNPC1UCHL1 | |
| SCHEMBL31226469 | 0.84 | ALOX5AP (0.45) | RIPK1LMNATSHRNPC1UCHL1 | |
| SCHEMBL28052467 | 0.84 | TACR1 (0.40) | LMNATSHR | |
| SCHEMBL31226409 | 0.84 | ALOX5AP (0.45) | RIPK1LMNATSHRNPC1UCHL1 | |
| SCHEMBL30679850 | 0.84 | ALOX5AP (0.45) | RIPK1LMNATSHRNPC1UCHL1 | |
| SCHEMBL31413078 | 0.84 | ALDH1A1 (0.52) | RIPK1LMNATSHRUCHL1ALDH1A1 | |
| SCHEMBL932475 | 0.84 | NTRK1 (0.50) | RIPK1 | |
| SCHEMBL932474 | 0.84 | NTRK1 (0.50) | RIPK1 | |
| SCHEMBL17041234 | 0.84 | RIPK1 (0.50) | RIPK1LMNATSHRNPC1UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125829-A2 | BICYCLIC OXOMORPHOLINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008108378-A2 | BICYCLIC OXOMORPHOLINE DERIVATIVE | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-09-12 | — | — | WO | disclosed |