Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TACR3 | P29371 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564979 | 0.90 | L3MBTL1 (0.50) | TP53L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL3343356 | 0.70 | POLB (0.57) | TP53L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL10863962 | 0.69 | L3MBTL1 (0.61) | L3MBTL1KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL7169284 | 0.68 | CYP1A2 (0.43) | TP53L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL3996960 | 0.68 | LMNA (0.47) | TP53L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL11680071 | 0.66 | MEN1 (0.42) | TP53LMNAGAAMAPTCYP1A2 | |
| SCHEMBL15561024 | 0.66 | GAA (0.62) | TP53L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL4904048 | 0.66 | L3MBTL1 (0.41) | TP53L3MBTL1ALDH1A1NPC1RAB9A | |
| SCHEMBL27616510 | 0.66 | CYP1A2 (0.56) | L3MBTL1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL6331041 | 0.66 | ALDH1A1 (1.00) | L3MBTL1KDM4EALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511065-B2 | Mixed lineage kinase modulators | ELI LILLY AND COMPANY (US) | 2009-03-31 | — | — | US | disclosed |
| US-20080113977-A1 | Mixed Lineage Kinase Modulators | ELI LILLY AND COMPANY | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113977-A1 | Mixed Lineage Kinase Modulators | MYLK2, CSNK1G2, CSNK1A1 | TP53 1917/4885L3MBTL1 1766/4885KDM4E 2001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.