SCHEMBL4565295

SCHEMBL4565295

CC(C)c1cc(-c2ccccn2)c(O)cc1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 8/20 0.49
HSP90AB1 P08238 7/20 0.46
GABRA1 P14867 1/20 0.46
GABRB2 P47870 1/20 0.46
KDM1A O60341 4/20 0.44
HTT P42858 1/20 0.44
LMNA P02545 2/20 0.42
KDM4E B2RXH2 2/20 0.42
CYP1A2 P05177 1/20 0.42
POLB P06746 1/20 0.42
CCR1 P32246 1/20 0.42
CCR5 P51681 1/20 0.42
CCR8 P51685 1/20 0.42
METAP1 P53582 1/20 0.42
BLM P54132 1/20 0.42
HIF1A Q16665 1/20 0.42
DOHH Q9BU89 1/20 0.42
P4HTM Q9NXG6 1/20 0.42
TRPA1 O75762 1/20 0.42
CHRM1 P11229 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28701272 0.81 HSP90AA1 (0.45) HSP90AA1HSP90AB1GABRA1GABRB2HTT
SCHEMBL8227726 0.77 KDM4E (0.50) HSP90AA1GABRA1GABRB2HTTLMNA
SCHEMBL29986460 0.75 KDM4E (0.48) HSP90AA1GABRA1GABRB2HTTLMNA
Ethane SCHEMBL27829996 0.75 KDM4E (0.48) HSP90AA1GABRA1GABRB2HTTLMNA
SCHEMBL28439262 0.75 GABRA1 (0.47) HSP90AA1GABRA1GABRB2KDM1AHTT
SCHEMBL28439261 0.75 KDM4E (0.43) HSP90AA1KDM1AHTTLMNAKDM4E
SCHEMBL19241404 0.73 KDM4E (0.44) HSP90AA1HTTLMNAKDM4ECYP1A2
SCHEMBL13848409 0.73 TRPM8 (0.44) HTTLMNAKDM4ECYP1A2POLB
SCHEMBL2734764 0.73 KDM4E (0.50) HSP90AA1KDM1AHTTLMNAKDM4E
SCHEMBL21363250 0.73 HSP90AA1 (0.64) HSP90AA1HSP90AB1GABRA1GABRB2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009066060-A2 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE TOPOTARGET A/S (DK) 2009-05-28 WO disclosed
WO-2009066060-A2 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE TOPOTARGET A/S (DK) 2009-05-28 WO disclosed