Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410129 | 0.90 | MEN1 (0.44) | MAPTMAPK14RAB9ANPC1CYP1A2 | |
| SCHEMBL14473102 | 0.89 | USP2 (0.43) | MAPTTHRBMAPK14MAPK11APEX1 | |
| SCHEMBL4413425 | 0.89 | GAA (0.39) | MAPTTHRBPOLBRAB9ACYP1A2 | |
| SCHEMBL4411278 | 0.88 | MAPT (0.37) | MAPTTHRBRAB9ANPC1CYP1A2 | |
| SCHEMBL4411132 | 0.88 | BRAF (0.38) | MAPTTHRBMAPK14CYP1A2CYP3A4 | |
| SCHEMBL4410028 | 0.85 | MAPT (0.38) | MAPTTHRBMAPK14CYP1A2CYP3A4 | |
| SCHEMBL4420133 | 0.83 | RAB9A (0.48) | RAB9ANPC1CYP1A2KMT2AALDH1A1 | |
| SCHEMBL4412714 | 0.83 | MAPT (0.35) | MAPTTHRBMAPK14CYP1A2CYP3A4 | |
| SCHEMBL4409883 | 0.82 | MAPK14 (0.36) | MAPTMAPK14CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4414341 | 0.82 | USP30 (0.40) | MAPK14MAPK11RAB9ANPC1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |