Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593243 | 0.89 | NPC1 (0.43) | MAPTTHRBNPC1RAB9AGAA | |
| SCHEMBL4565792 | 0.88 | MAPT (0.41) | MAPTTHRBNPC1RAB9ABRAF | |
| SCHEMBL4411132 | 0.87 | BRAF (0.38) | MAPTTHRBBRAFRAF1CYP1A2 | |
| SCHEMBL4410129 | 0.86 | MEN1 (0.44) | MAPTNPC1RAB9ANAMPTBRAF | |
| SCHEMBL4410261 | 0.85 | NPC1 (0.39) | MAPTTHRBNPC1RAB9AALDH1A1 | |
| SCHEMBL4420133 | 0.83 | RAB9A (0.48) | ROCK2NPC1RAB9AGAABRAF | |
| SCHEMBL4410028 | 0.82 | MAPT (0.38) | MAPTTHRBBRAFRAF1KDM4E | |
| SCHEMBL4414341 | 0.81 | USP30 (0.40) | NPC1RAB9ANAMPTBRAFRAF1 | |
| SCHEMBL4409883 | 0.81 | MAPK14 (0.36) | MAPTBRAFRAF1KDM4EALDH1A1 | |
| SCHEMBL5603582 | 0.80 | MAPK14 (0.37) | MAPTBRAFRAF1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |