Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.37 |
| ▸ | FRK | P42685 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412696 | 0.90 | USP30 (0.40) | USP30RAF1BRAFGSK3A | |
| SCHEMBL4420133 | 0.89 | RAB9A (0.48) | RAF1BRAFNPC1RAB9A | |
| SCHEMBL4569989 | 0.88 | DRD2 (0.44) | RAB9A | |
| SCHEMBL4411132 | 0.86 | BRAF (0.38) | MAPK14RAF1BRAF | |
| SCHEMBL4565792 | 0.82 | MAPT (0.41) | MAPK14BRAFMAPK11NPC1RAB9A | |
| SCHEMBL4413451 | 0.82 | RAF1 (0.36) | USP30MAPK14RAF1BRAF | |
| SCHEMBL4410227 | 0.82 | MAPK14 (0.38) | MAPK14RAF1BRAF | |
| SCHEMBL4411278 | 0.81 | MAPT (0.37) | RAF1BRAFNAMPTNPC1RAB9A | |
| SCHEMBL4410129 | 0.81 | MEN1 (0.44) | MAPK14BRAFNAMPTNPC1RAB9A | |
| SCHEMBL14473174 | 0.80 | RAF1 (0.36) | MAPK14RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |