Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565792 | 0.90 | MAPT (0.41) | MEN1KMT2AMAPK14ALDH1A1MAPT | |
| SCHEMBL14473103 | 0.90 | MEN1 (0.46) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL4411132 | 0.87 | BRAF (0.38) | MEN1KMT2AMAPK14MAPTBRAF | |
| SCHEMBL4411278 | 0.86 | MAPT (0.37) | ALDH1A1MAPTNAMPTBRAFNPC1 | |
| SCHEMBL4419761 | 0.86 | CYP1A2 (0.49) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL5593016 | 0.84 | TEK (0.53) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL4410028 | 0.83 | MAPT (0.38) | MAPK14MAPTBRAFSMN1; SMN2CYP1A2 | |
| SCHEMBL4420133 | 0.83 | RAB9A (0.48) | KMT2AALDH1A1LMNABRAFTSHR | |
| SCHEMBL4409883 | 0.82 | MAPK14 (0.36) | MAPK14ALDH1A1MAPTBRAFSMN1; SMN2 | |
| SCHEMBL4414341 | 0.81 | USP30 (0.40) | MAPK14NAMPTBRAFNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |