Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414341 | 0.89 | USP30 (0.40) | RAB9ANPC1RAF1BRAF | |
| SCHEMBL4569989 | 0.88 | DRD2 (0.44) | RAB9AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4411132 | 0.88 | BRAF (0.38) | KMT2ARAF1BRAFCYP1A2 | |
| SCHEMBL4409369 | 0.86 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL5593020 | 0.84 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL4565792 | 0.83 | MAPT (0.41) | RAB9ANPC1KMT2AALDH1A1BRAF | |
| SCHEMBL4412696 | 0.83 | USP30 (0.40) | RAF1BRAF | |
| SCHEMBL4411278 | 0.83 | MAPT (0.37) | RAB9ANPC1KDM4EALDH1A1RAF1 | |
| SCHEMBL4410129 | 0.83 | MEN1 (0.44) | RAB9ANPC1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL4413451 | 0.82 | RAF1 (0.36) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |