Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 2/20 | 0.36 |
| ▸ | RARB | P10826 | 2/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566136 | 1.00 | PDK2 (0.41) | PDK2MAPTMEN1KMT2AGLA | |
| SCHEMBL4628825 | 0.88 | RARB (0.39) | RARARARBRARG | |
| SCHEMBL4563580 | 0.85 | MEN1 (0.35) | MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL4565660 | 0.84 | PDK2 (0.41) | PDK2MAPTMEN1KMT2A | |
| SCHEMBL4564518 | 0.82 | LTB4R (0.38) | — | |
| SCHEMBL4563416 | 0.82 | LTB4R (0.36) | RARARARBRARGL3MBTL1 | |
| SCHEMBL4657250 | 0.82 | LMNA (0.38) | PDK2MAPTL3MBTL1 | |
| SCHEMBL4564083 | 0.81 | TSHR (0.42) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL4563452 | 0.80 | PTGS2 (0.39) | MAPTL3MBTL1 | |
| SCHEMBL4564341 | 0.78 | HSD11B1 (0.39) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125825-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079139-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
| EP-1907395-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007002867-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |