Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564158 | 0.93 | HTR2B (0.36) | ALDH1A1GAAL3MBTL1BACE1HSP90AA1 | |
| SCHEMBL4564228 | 0.87 | CACNA1B (0.35) | DRD2DRD3HCRTR2BRD4BRD2 | |
| SCHEMBL4628825 | 0.86 | RARB (0.39) | HCRTR2BRD4BRD2BRD3 | |
| SCHEMBL4564105 | 0.85 | PDE4A (0.37) | HCRTR2BRD4BRD2BRD3PDK2 | |
| SCHEMBL4563452 | 0.85 | PTGS2 (0.39) | LMNAALDH1A1MAPTNPSR1GAA | |
| SCHEMBL4564341 | 0.83 | HSD11B1 (0.39) | LMNAMAPTSMN1; SMN2DRD2DRD3 | |
| SCHEMBL4629499 | 0.83 | HSP90AA1 (0.39) | LMNAALDH1A1MAPTGAAL3MBTL1 | |
| SCHEMBL4564085 | 0.83 | HSP90AA1 (0.39) | ALDH1A1GAAL3MBTL1CYP19A1DRD2 | |
| SCHEMBL4658162 | 0.82 | HCRTR2 (0.36) | LMNAALDH1A1NPSR1GAAL3MBTL1 | |
| SCHEMBL4564518 | 0.82 | LTB4R (0.38) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907395-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007002867-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |