Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082959 | 0.80 | IMPDH2 (0.38) | IMPDH2XDHABCC1TSHRNPSR1 | |
| SCHEMBL4094828 | 0.78 | CA12 (0.35) | TSHR | |
| SCHEMBL4084945 | 0.76 | DYRK1A (0.41) | IMPDH2XDHABCC1 | |
| SCHEMBL13885170 | 0.73 | JAK2 (0.35) | XDHABCC1KDRTEK | |
| SCHEMBL4092944 | 0.71 | HTR2A (0.33) | TSHR | |
| SCHEMBL3892674 | 0.69 | TSHR (0.46) | IMPDH2TSHR | |
| SCHEMBL31106988 | 0.68 | IMPDH2 (0.61) | IMPDH2XDHTSHR | |
| SCHEMBL8266974 | 0.68 | IMPDH2 (0.61) | IMPDH2XDHTSHR | |
| SCHEMBL26259569 | 0.68 | CYP1A2 (0.41) | TSHR | |
| SCHEMBL21076079 | 0.68 | CA1 (0.39) | IMPDH2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |