Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 6/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | ESRRB | O95718 | 1/20 | 0.41 |
| ▸ | ESRRA | P11474 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786818 | 0.93 | ESR1 (0.53) | PTPN1PTPN11HSD17B10ESR1ESR2 | |
| SCHEMBL3811351 | 0.91 | ESR1 (0.51) | PTPN1PTPN11HSD17B10ESR1ESR2 | |
| SCHEMBL28600186 | 0.86 | ALOX5 (0.55) | PTPN1PTPN11ESR1ESR2JAK1 | |
| SCHEMBL4935679 | 0.83 | CA2 (0.50) | PTPN1PTPN11HSD17B10ALOX5 | |
| SCHEMBL465352 | 0.83 | TYR (0.58) | PTPN1HSD17B10ESR1ESR2ALOX5 | |
| SCHEMBL11012461 | 0.82 | JAK1 (0.50) | HSD17B10ESR1ESR2HSD17B1JAK1 | |
| SCHEMBL5931864 | 0.82 | ESR1 (0.58) | PTPN1PTPN11HSD17B10ESR1ESR2 | |
| SCHEMBL3807373 | 0.81 | TYR (0.56) | PTPN1HSD17B10ESR1ESR2ALOX5 | |
| SCHEMBL1678645 | 0.81 | CYP2C19 (0.61) | — | |
| SCHEMBL3809402 | 0.80 | HSD17B1 (0.51) | HSD17B10ESR1ESR2HSD17B1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114364716-A | Copolymer having hard polyamide blocks and soft blocks comprising polyethylene glycol | 阿科玛法国公司 | 2022-04-15 | — | — | CN | claimed |
| EP-2976314-B1 | METATHESIS PROCESS COMPRISING THE EXTRACTION OF THE ETHYLENE FORMED BY MEANS OF A MEMBRANE | ARKEMA FRANCE (FR) | 2020-12-16 | — | — | EP | claimed |
| US-20220315701-A1 | COPOLYMERS WITH HARD POLYAMIDE BLOCKS AND SOFT BLOCKS COMPRISING POLYETHYLENE GLYCOL | ARKEMA FRANCE (FR) | 2022-10-06 | — | — | US | disclosed |
| CN-114364716-A | Copolymer having hard polyamide blocks and soft blocks comprising polyethylene glycol | 阿科玛法国公司 | 2022-04-15 | — | — | CN | disclosed |
| US-20160002151-A1 | METATHESIS PROCESS COMPRISING THE EXTRACTION OF THE ETHYLENE FORMED BY MEANS OF A MEMBRANE | ARKEMA FRANCE (FR) | 2016-01-07 | — | — | US | disclosed |
| US-7547486-B2 | electricity generating power source for cellular or mobile telephones, and handheld or laptop computers; comprising a proton conducting membrane for catalytically oxidizing methanol to electricity; non-metallic microporous membrane for improve the efficient of removing by-product | CELGARD LLC (US) | 2009-06-16 | — | — | US | disclosed |
| US-20050202307-A1 | Direct methanol fuel cell | CELGARD LLC | 2005-09-15 | — | — | US | disclosed |
| EP-1575114-A2 | Direct methanol fuel cell | CELGARD LLC (US) | 2005-09-14 | — | — | EP | disclosed |
| CN-1667861-A | Direct methanol fuel cell | CELGARD LLC (US) | 2005-09-14 | — | — | CN | disclosed |
| US-6180719-B1 | MOLDING MATERIAL OF AN EPOXIDIZED BLOCK COPOLYMER OF A VINYL AROMATIC HYDROCARBON AND CONJUGATED DIENE, OR HYDROGENATED PRODUCTS THEREOF, AND SPECIFIED THERMOPLASTIC ELASTOMER(S); MOLDINGS SUCH AS TURNTABLE OF A CD-ROM DRIVER | DAICEL CHEMICAL INDUSTRIES LTD (JP) | 2001-01-30 | — | — | US | disclosed |
| EP-0878505-A1 | HEAT-FUSIBLE COMPOSITIONS AND MULTI-LAYER MOLDINGS COMPRISING LAYERS MADE THEREFROM | Daicel Chemical Industries, Ltd. (JP) | 1998-11-18 | — | — | EP | disclosed |
| EP-0124028-B1 | HETEROGENEOUS MEMBRANE AND PROCESS FOR PRODUCTION THEREOF | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1990-03-14 | — | — | EP | disclosed |
| US-4664681-A | SEPARATORS OF GAS MIXTURES | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1987-05-12 | — | — | US | disclosed |
| EP-0124028-A2 | Heterogeneous membrane and process for production thereof | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1984-11-07 | — | — | EP | disclosed |
| US-4391889-A | Electrophotographic photosensitive member with benzimidazole ring containing hydrazones | CANON KABUSHIKI KAISHA (JP) | 1983-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002151-A1 | METATHESIS PROCESS COMPRISING THE EXTRACTION OF THE ETHYLENE FORMED BY MEANS OF A MEMBRANE | ECH1, MAX, CYP8B1 | PTPN1 4842/4885PTPN11 4808/4885HSD17B10 1080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.