Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.56 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ALB | P02768 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21303704 | 1.00 | SIRT1 (0.56) | SIRT1SIRT6SIRT5FOLH1KDM4E | |
| SCHEMBL20705255 | 0.90 | FOLH1 (0.52) | SIRT1SIRT6SIRT5FOLH1KDM4E | |
| SCHEMBL14947853 | 0.88 | SIRT6 (0.50) | SIRT1SIRT6SIRT5FOLH1KDM4E | |
| SCHEMBL20411663 | 0.88 | KDM4E (0.52) | SIRT1SIRT6SIRT5FOLH1KDM4E | |
| SCHEMBL18117452 | 0.88 | KDM4E (0.52) | SIRT1SIRT6SIRT5FOLH1KDM4E | |
| SCHEMBL15218260 | 0.88 | KDM4E (0.52) | SIRT1SIRT6SIRT5FOLH1KDM4E | |
| SCHEMBL19057917 | 0.86 | KDM4E (0.55) | SIRT1SIRT6SIRT5FOLH1KDM4E | |
| SCHEMBL22920564 | 0.85 | SIRT1 (0.56) | SIRT1SIRT6SIRT5FOLH1ALB | |
| SCHEMBL11887166 | 0.84 | KDM4E (0.56) | SIRT1SIRT6SIRT5FOLH1KDM4E | |
| SCHEMBL10408291 | 0.84 | KDM4E (0.56) | SIRT1SIRT6SIRT5FOLH1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230175036-A1 | SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION | ENZO LIFE SCIENCES, INC. (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230175036-A1 | SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION | ENZO LIFE SCIENCES, INC. (US) | 2023-06-08 | — | — | US | disclosed |
| US-11661621-B2 | Self-immolative probes for enzyme activity detection | ENZO LIFE SCIENCES, INC. (US) | 2023-05-30 | — | — | US | disclosed |
| US-11661621-B2 | Self-immolative probes for enzyme activity detection | ENZO LIFE SCIENCES, INC. (US) | 2023-05-30 | — | — | US | disclosed |
| US-20200291448-A1 | SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION | ENZO LIFE SCIENCES, INC. (US) | 2020-09-17 | — | — | US | disclosed |
| US-10718005-B2 | Self-immolative probes for enzyme activity detection | Enzo Life Sciences, Inc (US) | 2020-07-21 | — | — | US | disclosed |
| US-20190119719-A1 | SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION | ENZO LIFE SCIENCES, INC. (US) | 2019-04-25 | — | — | US | disclosed |
| US-20170137863-A1 | Self-Immolative Probes for Enzyme Activity Detection | ENZO LIFE SCIENCES, INC., C/O ENZO BIOCHEM, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170137863-A1 | Self-Immolative Probes for Enzyme Activity Detection | ENZO LIFE SCIENCES, INC., C/O ENZO BIOCHEM, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| EP-2640805-B1 | SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION | ENZO BIOCHEM INC (US) | 2017-04-19 | — | — | EP | disclosed |
| US-9574222-B2 | Self-immolative probes for enzyme activity detection | ENZO LIFE SCIENCES, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| US-9574222-B2 | Self-immolative probes for enzyme activity detection | ENZO LIFE SCIENCES, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| US-20150191768-A1 | SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2015-07-09 | — | — | US | disclosed |
| US-8828678-B2 | Self-immolative probes for enzyme activity detection | ENZO LIFE SCIENCES, INC. (US) | 2014-09-09 | — | — | US | disclosed |
| WO-2012074693-A1 | SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION | ENZO BIOCHEM, INC. (US) | 2012-06-07 | — | — | WO | disclosed |
| US-20120122136-A1 | Self-immolative probes for enzyme activity detection | ENZO LIFE SCIENCES, INC., C/O ENZO BIOCHEM, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122136-A1 | Self-immolative probes for enzyme activity detection | ENZO LIFE SCIENCES, INC., C/O ENZO BIOCHEM, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-7838595-B2 | high purity; storage stability; electrophilically activated polymer derivatives with aldehyde functionality for conjugating to biologically active molecules; drug-polymer conjugate; | NEKTAR THERAPEUTICS (US) | 2010-11-23 | — | — | US | disclosed |
| US-20090234070-A1 | high purity; storage stability; electrophilically activated polymer derivatives with aldehyde functionality for conjugating to biologically active molecules; drug-polymer conjugate; | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122136-A1 | Self-immolative probes for enzyme activity detection | SORD, SI, IMMT | SIRT1 1701/4885SIRT6 1956/4885SIRT5 1192/4885 |
| US-20230175036-A1 | SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION | SORD, SI, IMMT | SIRT1 1701/4885SIRT6 1956/4885SIRT5 1192/4885 |
| US-11661621-B2 | Self-immolative probes for enzyme activity detection | MGAM, SI, ENGASE | SIRT1 1345/4885SIRT6 1273/4885SIRT5 1160/4885 |
| US-20170137863-A1 | Self-Immolative Probes for Enzyme Activity Detection | MGAM, SI, ENGASE | SIRT1 1345/4885SIRT6 1273/4885SIRT5 1160/4885 |
| US-20200291448-A1 | SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION | MGAM, SI, ENGASE | SIRT1 1345/4885SIRT6 1273/4885SIRT5 1160/4885 |
| US-20190119719-A1 | SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION | MGAM, SI, ENGASE | SIRT1 1345/4885SIRT6 1273/4885SIRT5 1160/4885 |
| US-10718005-B2 | Self-immolative probes for enzyme activity detection | MGAM, SI, ENGASE | SIRT1 1345/4885SIRT6 1273/4885SIRT5 1160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.