Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | XPO1 | O14980 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12457410 | 0.88 | KDM4E (0.41) | MEN1KMT2ALMNANPSR1NPY2R | |
| SCHEMBL457432 | 0.87 | MEN1 (0.51) | MEN1KMT2ALMNANPSR1BACE1 | |
| SCHEMBL459024 | 0.80 | LMNA (0.43) | MEN1KMT2ALMNANPSR1 | |
| SCHEMBL470212 | 0.78 | MEN1 (0.51) | MEN1KMT2ALMNANPSR1BACE1 | |
| SCHEMBL458554 | 0.77 | NPY2R (0.42) | MEN1KMT2ALMNABACE1NPY2R | |
| SCHEMBL470197 | 0.77 | MEN1 (0.47) | MEN1KMT2ALMNANPSR1BACE1 | |
| SCHEMBL470229 | 0.76 | MEN1 (0.46) | MEN1KMT2ALMNANPSR1BACE1 | |
| SCHEMBL6164833 | 0.76 | KDM4E (0.41) | MEN1KMT2ALMNANPSR1NPC1 | |
| SCHEMBL6166440 | 0.76 | KDM4E (0.39) | MEN1KMT2ADRD2LMNANPSR1 | |
| SCHEMBL15414721 | 0.75 | GPR35 (0.40) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614052-A1 | NOVEL PIPERAZINE ANALOGS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | Bristol-Myers Squibb Company (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033736-A1 | NOVEL PIPERAZINE ANALOGS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-15 | — | — | WO | disclosed |