SCHEMBL4569085

SCHEMBL4569085

C[C@H](CO)[C@@H](O[Si](C)(C)C)c1cccc(OC2CCCCO2)c1

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.42
HSD11B1 P28845 1/20 0.37
KDM4C Q9H3R0 1/20 0.34
POLB P06746 1/20 0.33
PTGER4 P35408 1/20 0.32
SLC6A3 Q01959 5/20 0.32
S1PR3 Q99500 2/20 0.32
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
TNK2 Q07912 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15149786 0.84 FFAR1 (0.39) DHFRSLC6A3
SCHEMBL4569089 0.82 CYP1A2 (0.38) DHFRKDM4CPOLBNPC1RAB9A
SCHEMBL4569090 0.78 GPR88 (0.42)
SCHEMBL2208196 0.78 GPR88 (0.42)
SCHEMBL17031437 0.77 DHFR (0.35) DHFRHSD11B1POLBSLC6A3S1PR3
SCHEMBL10183535 0.77 DHFR (0.45) DHFRHSD11B1KDM4CPOLBSLC6A3
SCHEMBL13779680 0.76 DHFR (0.44) DHFRHSD11B1KDM4CSLC6A3
SCHEMBL19291655 0.75 DHFR (0.43) DHFRHSD11B1KDM4C
SCHEMBL3964542 0.74 DHFR (0.45) DHFRHSD11B1KDM4CPOLBSLC6A3
SCHEMBL10250079 0.74 DHFR (0.41) DHFRHSD11B1POLBPTGER4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029708-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2024-07-09 US disclosed
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 US disclosed
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2021-03-18 US disclosed
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2019-06-20 US disclosed
US-10188615-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2019-01-29 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
US-9737496-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2017-08-22 US disclosed
US-9737496-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2017-08-22 US disclosed
US-20170049722-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2017-02-23 US disclosed
US-8993807-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-03-31 US disclosed
US-8981153-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-03-17 US disclosed
US-8981153-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-03-17 US disclosed
US-8829244-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2014-09-09 US disclosed
US-8829244-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2014-09-09 US disclosed
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-08-23 US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 US disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029708-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER DHFR 1728/4885HSD11B1 256/4885KDM4C 2559/4885
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER DHFR 1728/4885HSD11B1 256/4885KDM4C 2559/4885
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER DHFR 1728/4885HSD11B1 256/4885KDM4C 2559/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER DHFR 1785/4885HSD11B1 234/4885KDM4C 2474/4885
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER DHFR 1728/4885HSD11B1 256/4885KDM4C 2559/4885
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER DHFR 1728/4885HSD11B1 256/4885KDM4C 2559/4885
US-20090326074-A1 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER DHFR 1728/4885HSD11B1 256/4885KDM4C 2559/4885
US-20170049722-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER DHFR 1728/4885HSD11B1 256/4885KDM4C 2559/4885
US-10188615-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER DHFR 1728/4885HSD11B1 256/4885KDM4C 2559/4885
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER DHFR 1728/4885HSD11B1 256/4885KDM4C 2559/4885
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER DHFR 1728/4885HSD11B1 256/4885KDM4C 2559/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.