SCHEMBL4569126

SCHEMBL4569126

CB(O)NCCC(O)c1cccc(OCCCC(=O)O)c1

nearest known ligand 0.50

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYSLTR2 Q9NS75 4/20 0.45
CYSLTR1 Q9Y271 4/20 0.45
ALDH1A1 P00352 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
KDM4E B2RXH2 2/20 0.41
LMNA P02545 1/20 0.41
HPGD P15428 1/20 0.40
LTB4R Q15722 1/20 0.40
NSD2 O96028 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4569127 0.91 LTB4R (0.42) CYSLTR2CYSLTR1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL4569128 0.91 L3MBTL1 (0.45) CYSLTR2CYSLTR1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL12433002 0.87 CYSLTR2 (0.44) CYSLTR2CYSLTR1ALDH1A1LTB4R
SCHEMBL4569133 0.85 CYSLTR2 (0.50) CYSLTR2CYSLTR1ALDH1A1SMN1; SMN2LMNA
SCHEMBL4569132 0.85 MAPK1 (0.40) CYSLTR2CYSLTR1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL12433012 0.82 ADRB2 (0.41) CYSLTR2CYSLTR1ALDH1A1SMN1; SMN2LMNA
SCHEMBL4572133 0.81 CYSLTR2 (0.44) CYSLTR2CYSLTR1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL2206208 0.80 HPGD (0.43) CYSLTR2CYSLTR1HPGD
SCHEMBL25823428 0.77 L3MBTL1 (0.49) ALDH1A1SMN1; SMN2KDM4ELMNALTB4R
SCHEMBL27996046 0.76 HPGD (0.51) ALDH1A1SMN1; SMN2KDM4ELMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
US-9737496-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2017-08-22 US disclosed
US-20170049722-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2017-02-23 US disclosed
US-9458088-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2016-10-04 US disclosed
US-20150239836-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2015-08-27 US disclosed
US-20150239825-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2015-08-27 US disclosed
US-9079825-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-07-14 US disclosed
US-8993807-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-03-31 US disclosed
US-8981153-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-03-17 US disclosed
US-8829244-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2014-09-09 US disclosed
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA, INC. (US) 2013-08-01 US disclosed
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-08-23 US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 US disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150239836-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER CYSLTR2 456/4885CYSLTR1 417/4885ALDH1A1 140/4885
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER CYSLTR2 456/4885CYSLTR1 417/4885ALDH1A1 140/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER CYSLTR2 455/4885CYSLTR1 420/4885ALDH1A1 133/4885
US-20150239825-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER CYSLTR2 456/4885CYSLTR1 417/4885ALDH1A1 140/4885
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER CYSLTR2 456/4885CYSLTR1 417/4885ALDH1A1 140/4885
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER CYSLTR2 456/4885CYSLTR1 417/4885ALDH1A1 140/4885
US-20090326074-A1 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER CYSLTR2 456/4885CYSLTR1 417/4885ALDH1A1 140/4885
US-20170049722-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER CYSLTR2 456/4885CYSLTR1 417/4885ALDH1A1 140/4885
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER CYSLTR2 456/4885CYSLTR1 417/4885ALDH1A1 140/4885
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER CYSLTR2 456/4885CYSLTR1 417/4885ALDH1A1 140/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.