Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18094440 | 0.78 | LDHA (0.35) | LDHASLC6A4IDO1TDO2MEN1 | |
| SCHEMBL28869187 | 0.76 | SLC6A4 (0.49) | LDHASLC6A4MEN1KMT2AALDH1A1 | |
| SCHEMBL5140182 | 0.72 | IDO1 (0.44) | SLC6A4IDO1TDO2MEN1KMT2A | |
| SCHEMBL16111990 | 0.70 | IGF1R (0.42) | SLC6A4IDO1TDO2MEN1KMT2A | |
| SCHEMBL157708 | 0.69 | ALOX15 (0.50) | LDHASLC6A4MEN1KMT2AALDH1A1 | |
| SCHEMBL327420 | 0.69 | IDO1 (0.51) | SLC6A4IDO1TDO2MEN1KMT2A | |
| SCHEMBL9729013 | 0.67 | HTR2A (0.41) | IDO1TDO2MEN1KMT2AALDH1A1 | |
| SCHEMBL16111744 | 0.67 | HTR2A (0.37) | IDO1TDO2MEN1KMT2AALDH1A1 | |
| SCHEMBL7766235 | 0.66 | LDHA (0.47) | LDHASLC6A4MEN1KMT2AALDH1A1 | |
| SCHEMBL28384768 | 0.66 | LDHA (0.47) | LDHASLC6A4MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117535-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | Glaxo Group Limited (GB) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008090116-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | GLAXO GROUP LIMITED (GB) | 2008-07-31 | — | — | WO | disclosed |