SCHEMBL157708

SCHEMBL157708

FC(F)Oc1ccc(Br)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.50
LDHA P00338 1/20 0.50
GFER P55789 1/20 0.50
ADAM17 P78536 1/20 0.50
MAPT P10636 4/20 0.49
KDM4E B2RXH2 2/20 0.49
POLB P06746 1/20 0.49
DRD1 P21728 1/20 0.47
ALDH1A1 P00352 4/20 0.45
ATM Q13315 2/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
LMNA P02545 1/20 0.45
HSP90AA1 P07900 1/20 0.45
PKM P14618 1/20 0.45
HPGD P15428 1/20 0.45
HTT P42858 1/20 0.45
CCR6 P51684 1/20 0.45
CYP2A6 P11509 1/20 0.42
PPARG P37231 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11065049 0.86 DRD1 (0.56) ALOX15GFERADAM17MAPTKDM4E
SCHEMBL10337712 0.81 SLC6A4 (0.42) ALOX15LDHAGFERADAM17MAPT
SCHEMBL7766235 0.80 LDHA (0.47) ALOX15LDHAGFERADAM17MAPT
SCHEMBL28384768 0.80 LDHA (0.47) ALOX15LDHAGFERADAM17MAPT
SCHEMBL7818549 0.80 NCEH1 (0.47) ALOX15LDHAGFERADAM17MAPT
SCHEMBL13264261 0.78 DRD1 (0.68) ALOX15GFERADAM17MAPTDRD1
SCHEMBL3945052 0.77 LDHA (0.44) ALOX15LDHAGFERADAM17MAPT
SCHEMBL8266849 0.76 ALDH1A1 (0.49) ALOX15GFERADAM17MAPTKDM4E
SCHEMBL24901508 0.75 LDHA (0.47) ALOX15LDHAGFERADAM17MAPT
SCHEMBL2644146 0.74 DRD1 (0.52) ALOX15GFERADAM17MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 364 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115835909-B Cannabinoid receptor type 2 (CB 2) modulators and uses thereof 泰昂治疗公司 2026-05-15 CN disclosed
US-20260085048-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF EPIVARIO INC (US) 2026-03-26 US disclosed
EP-3897833-B1 INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMA (US) 2026-02-04 EP disclosed
US-12528802-B2 Heterocyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2026-01-20 US disclosed
EP-4674852-A1 PREPARATION METHOD FOR AND USE OF DIHYDROTHIENOPYRIMIDINE DERIVATIVE Innovstone Therapeutics Limited (CN) 2026-01-07 EP disclosed
US-12441689-B2 ACSS2 inhibitors and methods of use thereof EPIVARIO, INC. (US) 2025-10-14 US disclosed
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists BAYER AKTIENGESELLSCHAFT (DE) 2025-08-26 US disclosed
EP-4584259-A1 CK1ALPHA AND DUAL CK1ALPHA / GSPT1 DEGRADING COMPOUNDS Innovo Therapeutics, Inc. (US) 2025-07-16 EP disclosed
US-20250163068-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2025-05-22 US disclosed
EP-4373817-B1 SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2025-05-21 EP disclosed
US-5389292-A Liquid crystalline media having positive dielctric anisotropy, chemical, heat and radiation resistance, used as electro-optical displaying MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1995-02-14 US disclosed
EP-0637623-A1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-02-08 EP disclosed
CN-1023699-C Difluoromethyl compounds MERCK PATENT GMBH (DE) 1994-02-09 CN disclosed
EP-0381728-B1 DIFLUOROMETHYL COMPOUNDS MERCK PATENT GMBH (DE) 1993-12-08 EP disclosed
EP-0381728-A1 DIFLUOROMETHYL COMPOUNDS. MERCK PATENT GMBH (DE) 1990-08-16 EP disclosed
CN-1039797-A difluoromethyl compound MERCK PATENT GMBH (DE) 1990-02-21 CN disclosed
WO-1990001056-A1 DIFLUOROMETHYL COMPOUNDS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1990-02-08 WO disclosed
EP-0109606-B1 PROCESS FOR THE FORMYLATION OF ARYL HALIDES BAYER AG (DE) 1986-01-22 EP disclosed
US-4536344-A USING A PHOSPINE OR PHOSPHITE BAYER AKTIENGESELLSCHAFT (DE) 1985-08-20 US disclosed
EP-0109606-A1 Process for the formylation of aryl halides BAYER AG (DE) 1984-05-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250163068-A1 COMPOUNDS AND THEIR METHODS OF USE SCN1A, SCN3A, SCN1B ALOX15 2668/4885LDHA 2266/4885GFER 2239/4885
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists ADAMTS7, MMP7, ADAM17 ALOX15 3020/4885LDHA 4166/4885GFER 2364/4885
US-12528802-B2 Heterocyclic compound GBA2, GBA1, GALC ALOX15 2451/4885LDHA 1425/4885GFER 2035/4885
US-20260085048-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF ACSS2, GLS2, ACSL3 ALOX15 893/4885LDHA 254/4885GFER 3018/4885
US-12441689-B2 ACSS2 inhibitors and methods of use thereof ACSS2, ADSS2, GLS2 ALOX15 457/4885LDHA 350/4885GFER 2022/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.