Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE2 | P0DPD6 | 2/20 | 1.00 |
| ▸ | ECE1 | P42892 | 2/20 | 1.00 |
| ▸ | MUS81 | Q96NY9 | 2/20 | 1.00 |
| ▸ | AR | P10275 | 2/20 | 0.89 |
| ▸ | PGR | P06401 | 1/20 | 0.73 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.70 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.67 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16653949 | 1.00 | ECE2 (1.00) | ECE2ECE1MUS81ARPGR | |
| SCHEMBL29370806 | 1.00 | ECE2 (1.00) | ECE2ECE1MUS81ARPGR | |
| SCHEMBL29695489 | 1.00 | ECE2 (1.00) | ECE2ECE1MUS81ARPGR | |
| SCHEMBL29695645 | 1.00 | ECE2 (1.00) | ECE2ECE1MUS81ARPGR | |
| SCHEMBL30077227 | 1.00 | ECE2 (1.00) | ECE2ECE1MUS81ARPGR | |
| SCHEMBL16653952 | 1.00 | ECE2 (1.00) | ECE2ECE1MUS81ARPGR | |
| SCHEMBL14983767 | 0.94 | AR (1.00) | ECE2ECE1MUS81ARPGR | |
| SCHEMBL1175104 | 0.87 | AR (0.82) | ECE2ECE1MUS81ARPGR | |
| SCHEMBL1175103 | 0.87 | AR (0.82) | ECE2ECE1MUS81ARPGR | |
| SCHEMBL29874298 | 0.87 | AR (0.82) | ECE2ECE1MUS81ARPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11229629-B2 | Inhibitors of mitochondrial fission | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2022-01-25 | — | — | US | disclosed |
| US-20200323829-A1 | Inhibitors of Mitochondrial Fission | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2020-10-15 | — | — | US | disclosed |
| US-10253107-B2 | Use of endocytosis inhibitors and antibodies for cancer therapy | THE UNIVERSITY OF QUEENSLAND (AU) | 2019-04-09 | — | — | US | disclosed |
| US-20150284469-A1 | USE OF ENDOCYTOSIS INHIBITORS AND ANTIBODIES FOR CANCER THERAPY | THE UNIVERSITY OF QUEENSLAND (AU) | 2015-10-08 | — | — | US | disclosed |
| US-20150284469-A1 | USE OF ENDOCYTOSIS INHIBITORS AND ANTIBODIES FOR CANCER THERAPY | THE UNIVERSITY OF QUEENSLAND (AU) | 2015-10-08 | — | — | US | disclosed |
| US-8809386-B2 | Use of dynamin ring stabilizers | CHILDREN'S MEDICAL RESEARCH INSTITUTE (AU) | 2014-08-19 | — | — | US | disclosed |
| US-8809386-B2 | Use of dynamin ring stabilizers | CHILDREN'S MEDICAL RESEARCH INSTITUTE (AU) | 2014-08-19 | — | — | US | disclosed |
| US-20120122968-A1 | USE OF DYNAMIN RING STABILIZERS | THE GENERAL HOSPITAL CORPORATION (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122968-A1 | USE OF DYNAMIN RING STABILIZERS | THE GENERAL HOSPITAL CORPORATION (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10253107-B2 | Use of endocytosis inhibitors and antibodies for cancer therapy | CLINT1, CLTC, DNM1L | ECE2 1743/4885ECE1 869/4885MUS81 3891/4885 |
| US-20150284469-A1 | USE OF ENDOCYTOSIS INHIBITORS AND ANTIBODIES FOR CANCER THERAPY | CLINT1, CLTC, DNM1L | ECE2 1743/4885ECE1 869/4885MUS81 3891/4885 |
| US-11229629-B2 | Inhibitors of mitochondrial fission | FIS1, DNM1L, RHOT2 | ECE2 1885/4885ECE1 1174/4885MUS81 4721/4885 |
| US-20120122968-A1 | USE OF DYNAMIN RING STABILIZERS | DNM1L, DNM1, DNM2 | ECE2 1084/4885ECE1 760/4885MUS81 4653/4885 |
| US-20200323829-A1 | Inhibitors of Mitochondrial Fission | FIS1, DNM1L, RHOT2 | ECE2 1885/4885ECE1 1174/4885MUS81 4721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.