Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44225 | 0.90 | MAPT (0.50) | MAPTKDM4EMAPK1ALDH1A1LMNA | |
| SCHEMBL43952 | 0.85 | SMPD1 (0.36) | SMPD1MAPTLMNATHRBGSK3B | |
| SCHEMBL44296 | 0.84 | MARK3 (0.39) | MAPTLMNAKMT2ASMN1; SMN2POLB | |
| SCHEMBL44205 | 0.83 | SMPD1 (0.35) | SMPD1HPGD | |
| SCHEMBL44632 | 0.83 | LMNA (0.36) | SMPD1MAPTLMNATHRBPOLB | |
| SCHEMBL44454 | 0.83 | CHEK2 (0.36) | SMPD1MAPTLMNATHRBGSK3B | |
| SCHEMBL44541 | 0.82 | PDE4B (0.41) | MAPTMAPK1ALDH1A1RAB9AHPGD | |
| SCHEMBL44473 | 0.81 | GRM5 (0.40) | SMPD1MAPTLMNARAB9ATHRB | |
| SCHEMBL44556 | 0.81 | GSK3B (0.43) | GSK3BTSHR | |
| SCHEMBL44338 | 0.81 | WDR5 (0.41) | MAPTKDM4ELMNARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |