Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547433 | 0.84 | CRHR1 (0.34) | HPGDHSD17B10MAPTCRHR1ALDH1A1 | |
| SCHEMBL13384685 | 0.84 | CYP3A4 (0.45) | HPGDHSD17B10TUBB1MAPTCYP3A4 | |
| SCHEMBL4380347 | 0.81 | SHBG (0.44) | HPGDHSD17B10MAPTLMNAL3MBTL1 | |
| SCHEMBL23743654 | 0.80 | ALDH1A1 (0.44) | TUBB1MAPTLMNANPC1CYP3A4 | |
| SCHEMBL14853199 | 0.80 | HPGD (0.34) | HPGDHSD17B10MAPTLMNACRHR1 | |
| SCHEMBL9191718 | 0.80 | CA1 (0.46) | MAPTL3MBTL1CYP3A4ALDH1A1GAA | |
| SCHEMBL3504510 | 0.80 | ALDH1A1 (0.46) | HPGDHSD17B10LMNACYP3A4ALDH1A1 | |
| SCHEMBL3624689 | 0.80 | PRKCE (0.37) | MAPTLMNAL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL16597205 | 0.77 | ALDH1A1 (0.39) | HPGDHSD17B10MAPTLMNAL3MBTL1 | |
| SCHEMBL8728579 | 0.77 | RAPGEF4 (0.30) | RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130296352-A1 | PYRAZOLOQUINOLINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-11-07 | — | — | US | disclosed |
| US-8563565-B2 | Pyrazoloquinoline derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-10-22 | — | — | US | disclosed |
| US-20130143907-A1 | PYRAZOLOQUINOLINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-06-06 | — | — | US | disclosed |
| US-8173628-B2 | Therapy for hormone sensitive diseases; side effect reduction; anticancer agents; osteoporosis; endometriosis; benign prostatic hyperplasia; cardiovascular disorders; acne | NORTHEASTERN UNIVERSITY (US) | 2012-05-08 | — | — | US | disclosed |
| US-8173628-B2 | Therapy for hormone sensitive diseases; side effect reduction; anticancer agents; osteoporosis; endometriosis; benign prostatic hyperplasia; cardiovascular disorders; acne | NORTHEASTERN UNIVERSITY (US) | 2012-05-08 | — | — | US | disclosed |
| US-8124294-B2 | Polymer electrolyte membrane comprising inorganic nanoparticle bonded with proton-conducting group and solid acid, fuel cell including the same, and method of preparing the polymer electrolyte membrane | SAMSUNG SDI CO., LTD. (KR) | 2012-02-28 | — | — | US | disclosed |
| US-8119833-B2 | Dendrimer solid acid and polymer electrolyte membrane including the same | SAMSUNG SDI CO., LTD. (KR) | 2012-02-21 | — | — | US | disclosed |
| US-8049033-B2 | Dendrimer solid acid and polymer electrolyte membrane including the same | SAMSUNG SDI CO., LTD. (KR) | 2011-11-01 | — | — | US | disclosed |
| US-20110262833-A1 | DENDRIMER SOLID ACID AND POLYMER ELECTROLYTE MEMBRANE INCLUDING THE SAME | SAMSUNG SDI CO., LTD. (KR) | 2011-10-27 | — | — | US | disclosed |
| US-20080166301-A1 | Steroidal antiestrogens and antiandrogens and uses thereof | NORTHEASTERN UNIVERSITY | 2008-07-10 | — | — | US | disclosed |
| US-20080166301-A1 | Steroidal antiestrogens and antiandrogens and uses thereof | NORTHEASTERN UNIVERSITY | 2008-07-10 | — | — | US | disclosed |
| US-20080085441-A1 | POLYMER ELECTROLYTE MEMBRANE COMPRISING INORGANIC NANOPARTICLE BONDED WITH PROTON-CONDUCTING GROUP AND SOLID ACID, FUEL CELL INCLUDING THE SAME, AND METHOD OF PREPARING THE POLYMER ELECTROLYTE MEMBRANE | SAMSUNG SDI CO., LTD. (KR) | 2008-04-10 | — | — | US | disclosed |
| US-20070092778-A1 | Oligomer solid acid and polymer electrolyte membrane including the same | SAMSUNG SDI CO., LTD. (KR) | 2007-04-26 | — | — | US | disclosed |
| US-20070092779-A1 | Dendrimer solid acid and polymer electrolyte membrane including the same | SAMSUNG SDI CO., LTD. (KR) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143907-A1 | PYRAZOLOQUINOLINE DERIVATIVES | PDE2A, PDE3A, PDE3B | HPGD 256/4885HSD17B10 803/4885TUBB1 3186/4885 |
| US-20080166301-A1 | Steroidal antiestrogens and antiandrogens and uses thereof | NR5A1, SHBG, AR | HPGD 418/4885HSD17B10 89/4885TUBB1 4399/4885 |
| US-20130296352-A1 | PYRAZOLOQUINOLINE DERIVATIVES | PDE2A, PDE3A, PDE3B | HPGD 256/4885HSD17B10 803/4885TUBB1 3186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.