Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL6864894 | 0.98 | MEN1 (0.48) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL8618035 | 0.88 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL8616153 | 0.87 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7028618 | 0.83 | MEN1 (0.34) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9193688 | 0.82 | MEN1 (0.42) | MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL19856508 | 0.75 | MEN1 (0.50) | MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL16702277 | 0.75 | MEN1 (0.50) | MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL18729667 | 0.75 | MEN1 (0.50) | MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL8531348 | 0.73 | MEN1 (0.42) | MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL7652452 | 0.73 | MEN1 (0.42) | MEN1LMNAKMT2AS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020183574-A1 | Hydrocarbon conversion process | SASOL TECHNOLOGY (PTY) LTD. (ZA) | 2002-12-05 | — | — | US | claimed |
| EP-1235767-A1 | HYDROCARBON CONVERSION PROCESS | Sasol Technology (Proprietary) Limited (ZA) | 2002-09-04 | — | — | EP | claimed |
| WO-2002038637-A1 | METHOD FOR COPOLYMERIZING PROPENE AND/OR ETHENE WITH 1-OLEFINS ON METALLOCENE CARRIER CATALYSTS | BASELL POLYPROPYLEN GMBH (DE) | 2002-05-16 | — | — | WO | claimed |
| WO-2001038270-A1 | HYDROCARBON CONVERSION PROCESS | SASOL TECHNOLOGY (PTY) LTD (ZA) | 2001-05-31 | — | — | WO | claimed |
| EP-0632819-B1 | ADDITION POLYMERIZATION CATALYSTS COMPRISING REDUCED OXIDATION STATE METAL COMPLEXES | DOW CHEMICAL CO (US) | 1998-09-02 | — | — | EP | claimed |
| EP-3066140-B1 | STEREOREGULAR DIBLOCK POLYBUTADIENES HAVING A 1,4-CIS/SYNDIOTACTIC 1,2 STRUCTURE FROM STEREOSPECIFIC POLYMERIZATION | VERSALIS SPA (IT) | 2021-12-29 | — | — | EP | disclosed |
| EP-3066139-B1 | STEREOREGULAR DIBLOCK POLYBUTADIENES HAVING A 1,4-CIS/SYNDIOTACTIC 1,2 STRUCTURE FROM STEREOSPECIFIC POLYMERIZATION | VERSALIS SPA (IT) | 2019-02-20 | — | — | EP | disclosed |
| EP-3394121-A1 | PROCESS FOR THE PREPARATION OF (CO) POLYMERS OF CONJUGATED DIENES IN THE PRESENCE OF A CATALYTIC SYSTEM COMPRISING A VANADIUM BIS-IMINE COMPLEX | Versalis S.p.A. (IT) | 2018-10-31 | — | — | EP | disclosed |
| US-10093763-B2 | Stereoregular diblock polybutadienes having a 1,4-cis/syndiotactic 1,2 structure from stereospecific polymerization | VERSALIS S.P.A. (IT) | 2018-10-09 | — | — | US | disclosed |
| US-10066044-B2 | Stereoregular diblock polybutadienes having a 1,4-cis/syndiotactic 1,2 structure from stereospecific polymerization | VERSALIS S.P.A. (IT) | 2018-09-04 | — | — | US | disclosed |
| WO-2017109767-A1 | PROCESS FOR THE PREPARATION OF (CO) POLYMERS OF CONJUGATED DIENES IN THE PRESENCE OF A CATALYTIC SYSTEM COMPRISING A VANADIUM BIS-IMINE COMPLEX | VERSALIS S.P.A. (IT) | 2017-06-29 | — | — | WO | disclosed |
| EP-3155686-A1 | ELECTROLYTE, CELL AND BATTERY COMPRISING THE ELECTROLYTE, AND USE OF THE ELECTROLYTE | Karlsruher Institut Für Technologie (KIT) (DE) | 2017-04-19 | — | — | EP | disclosed |
| WO-1998009999-A2 | ALPHA-OLEFIN/VINYLIDENE AROMATIC MONOMER AND/OR HINDERED ALIPHATIC OR CYCLOALIPHATIC VINYLIDENE MONOMER INTERPOLYMERS | THE DOW CHEMICAL COMPANY (US) | 1998-03-12 | — | — | WO | disclosed |
| WO-1998010018-A1 | BLENDS OF α-OLEFIN/VINYLIDENE AROMATIC MONOMER AND/OR HINDERED ALIPHATIC OR CYCLOALIPHATIC VINYLIDENE MONOMER INTERPOLYMERS | THE DOW CHEMICAL COMPANY (US) | 1998-03-12 | — | — | WO | disclosed |
| WO-1998002469-A1 | SYNDIOTACTIC/ATACTIC BLOCK POLYOLEFINS, CATALYSTS AND PROCESSES FOR PRODUCING THE SAME | FINA RESEARCH S.A. (BE) | 1998-01-22 | — | — | WO | disclosed |
| WO-1997044371-A1 | POLYOLEFIN COMPOSITION WITH MOLECULAR WEIGHT MAXIMUM OCCURING IN THAT PART OF THE COMPOSITION THAT HAS THE HIGHEST COMONOMER CONTENT | THE DOW CHEMICAL COMPANY (US) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997034943-A1 | THERMOPLASTIC ELASTOMERIC CARBON MONOXIDE/OLEFIN COPOLYMERS | BASF AKTIENGESELLSCHAFT (DE) | 1997-09-25 | — | — | WO | disclosed |
| WO-1997031029-A1 | PROCESS FOR PRODUCING POLYMERS OF ALKENES BY SUSPENSION POLYMERISATION | BASF AKTIENGESELLSCHAFT (DE) | 1997-08-28 | — | — | WO | disclosed |
| WO-1997021742-A1 | PROCESS FOR THE PREPARATION OF POLYMERISATES OF VINYL AROMATIC COMPOUNDS IN A STAGE USING DOUBLE SCREW EXTRUDERS | BASF AKTIENGESELLSCHAFT (DE) | 1997-06-19 | — | — | WO | disclosed |
| WO-1997010286-A1 | PROPENE/BUT-1-ENE COPOLYMERS | BASF AKTIENGESELLSCHAFT (DE) | 1997-03-20 | — | — | WO | disclosed |