Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL457183 | 0.83 | MEN1 (0.50) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL6864894 | 0.81 | MEN1 (0.48) | MEN1LMNAKMT2A | |
| SCHEMBL5358108 | 0.81 | HSD17B10 (0.33) | HSD17B10 | |
| SCHEMBL5349019 | 0.77 | HSD17B10 (0.35) | MEN1KMT2AHSD17B10 | |
| Tromethamine SCHEMBL8618035 | 0.77 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL8616153 | 0.76 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| SCHEMBL7784272 | 0.70 | HSD17B10 (0.32) | HSD17B10 | |
| Tromethamine SCHEMBL9193688 | 0.68 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| SCHEMBL182607 | 0.67 | HSD17B10 (0.40) | MEN1KMT2AHSD17B10 | |
| SCHEMBL3763099 | 0.64 | HSD17B10 (0.41) | MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0903351-B1 | Handling method of (fluoroaryl) borane compound and preparing method of hydrocarbon solution | NIPPON CATALYTIC CHEM IND (JP) | 2003-01-22 | — | — | EP | disclosed |