Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL8618035 | 0.96 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL457183 | 0.87 | MEN1 (0.50) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL6864894 | 0.85 | MEN1 (0.48) | MEN1LMNAKMT2A | |
| SCHEMBL1753848 | 0.76 | — | — | |
| Tromethamine SCHEMBL7028618 | 0.76 | MEN1 (0.34) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7029632 | 0.76 | MEN1 (0.34) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9193688 | 0.75 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| SCHEMBL5352195 | 0.71 | — | — | |
| SCHEMBL25968105 | 0.69 | — | — | |
| Tromethamine SCHEMBL7510306 | 0.68 | MEN1 (0.77) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0838466-A2 | Producing process of (fluoroaryl) borane compound and producing process of tetrakis (fluoroaryl) borate derivative | NIPPON SHOKUBAI CO., LTD. (JP) | 1998-04-29 | — | — | EP | disclosed |