SCHEMBL457303

SCHEMBL457303

CCN(CC)c1ccc2cc(-c3nc4ccccc4n3C)c(=O)oc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 10/20 1.00
▸ NPC1 O15118 8/20 1.00
▸ KDM4E B2RXH2 8/20 1.00
▸ KMT2A Q03164 8/20 1.00
▸ MEN1 O00255 7/20 1.00
▸ SMN1; SMN2 Q16637 6/20 1.00
▸ ALDH1A1 P00352 6/20 1.00
▸ HTT P42858 4/20 1.00
▸ CASP1 P29466 3/20 1.00
▸ CASP7 P55210 3/20 1.00
▸ ATM Q13315 3/20 1.00
▸ NPSR1 Q6W5P4 3/20 1.00
▸ HBB P68871 2/20 1.00
▸ HSD17B10 Q99714 2/20 1.00
▸ HCRTR1 O43613 1/20 1.00
▸ TSHR P16473 1/20 1.00
▸ TLR9 Q9NR96 1/20 1.00
▸ L3MBTL1 Q9Y468 1/20 1.00
▸ RAB9A P51151 7/20 0.68
▸ HPGD P15428 5/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29357085 1.00 MAPT (1.00) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL29582969 0.99 MAPT (0.98) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL28830001 0.99 MAPT (0.98) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL30874254 0.92 MAPT (0.85) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL24220026 0.92 MAPT (0.85) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL21753748 0.91 NPC1 (0.82) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL26493464 0.90 MAPT (0.81) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL2202346 0.88 MAPT (0.79) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL23450211 0.88 MAPT (0.79) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL4506209 0.88 NPC1 (0.78) MAPTNPC1KDM4EKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 390 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118625598-A Two-photon photoresist based on polyhydroxystyrene and patterning method thereof 之江实验室 2024-09-10 — — CN claimed
CN-117384259-A Cell penetrating peptides based on influenza virus M2 proteins 中国医学科学院基础医学研究所 2024-01-12 — — CN claimed
CN-112912386-B Cell penetrating peptides based on influenza virus M2 proteins 中国医学科学院基础医学研究所 2023-10-20 — — CN claimed
CN-115236936-B Femtosecond laser cured and crosslinked polyamic acid photoresist and preparation method, use method and application thereof 之江实验室 2022-12-06 — — CN claimed
CN-115236936-A Femtosecond laser cured and crosslinked polyamic acid photoresist and preparation method, use method and application thereof 之江实验室 2022-10-25 — — CN claimed
CN-114415471-B Siloxane-based two-photon photoresist and preparation method, use method and application thereof 之江实验室 2022-09-02 — — CN claimed
US-20220169680-A1 CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2022-06-02 — — US claimed
CN-114415471-A Siloxane-based two-photon photoresist and preparation method, use method and application thereof 之江实验室 2022-04-29 — — CN claimed
EP-3912989-A1 CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN Institute of Basic Medical Sciences Chinese Academy of Medical Sciences (CN) 2021-11-24 — — EP claimed
CN-112912386-A Cell penetrating peptide based on influenza virus M2 protein 中国医学科学院基础医学研究所 2021-06-04 — — CN claimed
JP-2011517934-A — — 2011-06-23 — — JP claimed
WO-2011028698-A2 MRI AND OPTICAL ASSAYS FOR PROTEASES KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) 2011-03-10 — — WO claimed
EP-2260108-A2 PROTEASE ASSAY Kansas State University Research Foundation (US) 2010-12-15 — — EP claimed
WO-2009111470-A2 PROTEASE ASSAY KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) 2009-09-11 — — WO claimed
US-20090053192-A1 TISSUE-NONSPECIFIC ALKALINE PHOSPHATASE (TNAP) ACTIVATORS AND USES THEREOF BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) 2009-02-26 — — US claimed
US-20080224595-A1 Organic EL device FUJI ELECTRIC HOLDINGS CO., LTD. (JP) 2008-09-18 — — US claimed
US-20060084176-A1 Detection of uronium salts YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2006-04-20 — — US claimed
EP-0431452-B1 Method for the optical distinction of dental materials and material used in this method IVOCLAR AG (LI) 1994-10-05 — — EP claimed
US-5102461-A PROCESS FOR THE OPTICAL DISTINCTION OF A DENTAL MATERIAL AND DENTAL MATERIAL FOR SAID PROCESS IVOCLAR AG (DE) 1992-04-07 — — US claimed
EP-0431452-A2 Method for the optical distinction of dental materials and material used in this method IVOCLAR AG (LI) 1991-06-12 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090053192-A1 TISSUE-NONSPECIFIC ALKALINE PHOSPHATASE (TNAP) ACTIVATORS AND USES THEREOF ALPL, ALPP, ACP3 MAPT 4267/4885NPC1 3610/4885KDM4E 3830/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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